Molecular, parasitological and clinical diagnosis of female genital schistosomiasis: a diagnostic yield and comparative accuracy study using latent class analysis
{"Abstract":[0],"Background:":[1],"Female":[2],"genital":[3,74],"schistosomiasis":[4],"(FGS)":[5],"is":[6,16],"a":[7,22,80,121,141,150,202],"neglected":[8],"manifestation":[9],"of":[10,21,35,63,144,152,171,185,215],"Schistosoma":[11],"haematobium":[12],"infection":[13,211],"whose":[14],"diagnosis":[15],"restricted":[17],"by":[18,102,131],"the":[19,31,60,89,96,136,213],"absence":[20],"flawless":[23],"\\"gold":[24],"standard\\"":[25],"diagnostic":[26,217],"tool.":[27],"This":[28],"study":[29,48],"compared":[30],"yield,":[32],"accuracy,":[33],"performance":[34],"polymerase":[36],"chain":[37],"reaction":[38],"(PCR),":[39],"urine":[40,72,103,157],"egg":[41,104,158],"microscopy,":[42,73],"and":[43,67,77,79,107,119,149,160,176,190],"colposcopy.":[44],"Methods:":[45],"A":[46],"cross-sectional":[47],"was":[49,86],"conducted":[50],"among":[51],"143":[52],"female":[53],"participants":[54],"from":[55,205,242],"S.":[56],"haematobium-endemic":[57],"communities":[58],"in":[59],"West":[61],"Region":[62],"Cameroon":[64],"between":[65,233],"July":[66],"August":[68],"2024.":[69],"Participants":[70],"underwent":[71],"swab":[75],"PCR,":[76],"colposcopy,":[78],"two-class":[81],"latent":[82],"class":[83],"analysis":[84],"model":[85,199],"developed":[87],"using":[88],"R":[90],"package":[91],"poLCA.":[92],"Results:":[93],"PCR":[94,139,224],"yielded":[95],"highest":[97],"positivity":[98],"rate":[99],"(73.4%),":[100],"followed":[101],"microscopy":[105,159],"(29.4%)":[106],"colposcopy/Visual":[108],"FGS":[109,162],"(23.08%).":[110],"Among":[111],"women":[112,129],"with":[113,169,226],"visual":[114],"FGS,":[115],"68.75%":[116],"were":[117],"PCR-positive":[118],"had":[120],"lower":[122,183],"median":[123],"Ct":[124],"value":[125],"(29.6)":[126],"than":[127],"PCR-negative":[128],"(32.8)":[130],"SYBR":[132],"Green":[133],"PCR.":[134],"Within":[135],"LCA":[137,198],"framework,":[138],"provided":[140],"baseline":[142],"sensitivity":[143],"100.00%":[145],"(95%":[146,154,173,178,187,192],"CI:":[147,155,174,179,188,193],"94.85%–100.00%)":[148],"specificity":[151],"95.20%":[153],"91.88%–98.52%).":[156],"colposcopy/visual":[161],"served":[163],"as":[164,228],"highly":[165],"specific":[166],"rule-out":[167],"tools":[168,207],"specificities":[170],"83.32%":[172],"62.75%–100.00%)":[175],"83.33%":[177],"62.76%–100.00%),":[180],"despite":[181],"their":[182],"sensitivities":[184],"29.06%":[186],"17.5%–40.62%)":[189],"38.27%":[191],"29.92%–46.62%)":[194],"respectively.":[195],"Conclusion:":[196],"The":[197],"confirmed":[200],"that":[201],"negative":[203],"result":[204],"traditional":[206],"cannot":[208,231],"rule":[209],"out":[210],"necessitating":[212],"use":[214],"complementary":[216],"tools.":[218],"However,":[219],"clinicians":[220],"should":[221],"interpret":[222],"positive":[223],"outcomes":[225],"care,":[227],"molecular":[229],"detection":[230],"distinguish":[232],"active":[234],"infection,":[235],"recent":[236],"parasite":[237],"exposure,":[238],"or":[239],"residual":[240],"DNA":[241],"past":[243],"infections.":[244]}
Authors
- Adela Ngwewondo (ORCID: https://orcid.org/0000-0001-9469-3618)
- Clarisse Engowei Mbah (ORCID: https://orcid.org/0000-0001-8759-1234)
- Forgu Esemu Livo
- Godlove Bunda Wepnje (ORCID: https://orcid.org/0000-0001-8335-6624)
- Elvis Monya
- Roger Somo Moyou
- Kingsley Ombaku Sama
Publication Details
- Journal
- Parasitology Research
- Published
- 2026-09-18
- DOI
- https://doi.org/10.1007/s00436-026-08753-8
- Primary Topic
- Parasites and Host Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00