NP-SEE v6.1: Genomic Structural Analysis of Filoviruses and Emerging Pathogens -- Ebola Bundibugyo 2026 Epidemic Strain, Marburg Angola, CCHF, VZV, PRV

We report the results of a structural genomic analysis of 53 viral sequences conducted using NP-SEE v6.1, a non-parametric analysis framework that operates directly on raw genomic sequences without reference databases, known signatures, or free parameters. The corpus comprises 48 complete genomes of Ebola Bundibugyo virus (BDBV) from the ongoing 2026 epidemic in the Democratic Republic of Congo (DRC/Uganda), the reference BDBV 2007 strain, Marburg Angola 2005, CCHF IbAr10200, VZV, and PRV. Principal findings: (1) all 53 genomes show statistically non-random genomic structure (Lambda p<0.001, 1,000 bootstrap permutations); (2) the BDBV 2026 strain displays a mean G-quadruplex density 5.4-fold higher than the 2007 strain; (3) the internal structure is conserved between strains 2007 and 2026 (p=0.065, non-significant), suggesting that therapeutic targets identified on the historical strain apply to the current epidemic; (4) a pan-filoviral structural convergence zone in the first 500 nt of the genome (score >= 458) is identified in all filoviruses analysed. Keywords: Ebola Bundibugyo, Marburg, CCHF, genomic structural analysis, G-quadruplex, evolutionary constraints, antiviral targets, NP-SEE, non-parametric bootstrap, PHEIC 2026.