Methyl-HLH-30/TFEB orchestrates holistic intestinal recuperation against bacterial pore-forming toxin intoxication via TTC38 in metazoans
and human IECs. This conserved ETI system coordinates the restoration of PMI, microvilli architecture, and nutrient absorption concurrently by promoting phase condensation of the PTRN-1/CAMSAP-dependent guard program through an HSPA/HSP70-HSP90 chaperone system. Together, our findings reveal an intestinal ETI guard system that couples PFT-damage sensing to comprehensive epithelial recuperation, underscoring its physiological relevance for mucosal homeostasis across metazoans.
Authors
- Chyuan-Chuan Wu (ORCID: https://orcid.org/0000-0002-7389-8777)
- Raffi V. Aroian (ORCID: https://orcid.org/0000-0002-9741-3834)
- Chang‐Shi Chen (ORCID: https://orcid.org/0000-0002-8201-3635)
- Shao‐Wen Chang (ORCID: https://orcid.org/0000-0002-3576-919X)
- Jhen‐Wei Ruan (ORCID: https://orcid.org/0000-0002-0636-1937)
- Hui-Chen Hsieh
- Yi-Hsiu Weng (ORCID: https://orcid.org/0009-0003-9263-0172)
- Po‐Lin Chen (ORCID: https://orcid.org/0000-0002-4015-1052)
- Shuying Wang (ORCID: https://orcid.org/0000-0003-3339-8070)
- Yi-Lin Cheng (ORCID: https://orcid.org/0000-0002-3603-5913)
- Tzu-Hsuan Chiu
- Chee Kit Joshua Luk
- Yan-Ning Gu
- Ting-Wei Chang
- Tzer-Min Lee
Institutions
- University of Massachusetts Chan Medical School (US)
- National Cheng Kung University (TW)
Publication Details
- Journal
- Autophagy
- Published
- 2026-09-16
- DOI
- https://doi.org/10.1080/15548627.2026.2735736
- Primary Topic
- Bacterial Genetics and Biotechnology
- Type
- article
- Field-Weighted Citation Impact
- 0.00