The role of MEG cluster characteristics in defining the epileptogenic zone: A retrospective study of 101 seizure‐free patients

{"OBJECTIVE:":[0],"Magnetoencephalography":[1],"(MEG)":[2],"is":[3],"used":[4,135],"widely":[5],"in":[6,22,127,173,250,292,306],"presurgical":[7,272],"evaluation":[8,273],"of":[9,20,123,267,295],"medically":[10],"intractable":[11],"epilepsy.":[12],"Prior":[13],"research":[14],"has":[15],"documented":[16],"the":[17,119,128],"added":[18],"value":[19,305],"MEG":[21,29,57,88,268],"refining":[23],"surgical":[24,287],"strategies;":[25],"however,":[26],"not":[27,256],"all":[28],"clusters":[30,62,184,200,211,218,238,291],"require":[31],"resection":[32],"for":[33,49,279],"seizure":[34,251],"freedom,":[35],"suggesting":[36],"that":[37],"they":[38],"represent":[39],"nodes":[40],"within":[41],"a":[42,93,151],"broader":[43],"epileptic":[44],"network,":[45],"with":[46,72,92,118,148,198,240],"differing":[47],"importance":[48],"epileptogenic":[50],"zone":[51],"(EZ)":[52],"localization.":[53],"We":[54,68],"examined":[55],"whether":[56],"cluster":[58,162,269],"characteristics":[59,270],"can":[60],"identify":[61],"most":[63],"relevant":[64],"to":[65,136,185,204,274],"EZ.":[66],"METHODS:":[67],"studied":[69],"101":[70],"patients":[71,197],"focal":[73],"epilepsy":[74,157],"who":[75],"underwent":[76],"intracranial":[77],"electroencephalography":[78],"(ICEEG),":[79],"resective":[80],"surgery,":[81,160],"and":[82,96,112,114,143,161,175,191,231,246,298],"became":[83],"seizure-free":[84],"at":[85],"1":[86],"year.":[87],"recordings":[89],"were":[90,106,125,166,179,201,212,248],"obtained":[91],"306-channel":[94],"system":[95],"analyzed":[97],"using":[98],"single":[99],"equivalent":[100],"current":[101],"dipole":[102],"(SECD)":[103],"modeling.":[104],"Clusters":[105,172,195],"categorized":[107],"by":[108,258],"anatomic":[109],"location,":[110],"tightness,":[111],"orientation":[113],"defined":[115],"as":[116,150],"\\"matched\\"":[117],"EZ":[120,276],"if":[121],"≥70%":[122],"dipoles":[124],"included":[126],"resection.":[129],"A":[130],"sublobar":[131],"anatomo-functional":[132],"scheme":[133],"was":[134],"map":[137],"cluster-resection":[138],"spatial":[139],"relationships.":[140],"Logistic":[141],"regression":[142],"generalized":[144],"linear":[145],"mixed":[146],"models":[147],"patient":[149],"random":[152],"effect":[153],"evaluated":[154],"age,":[155],"sex,":[156],"duration,":[158],"prior":[159],"characteristics.":[163],"Match":[164,253],"rates":[165,254],"compared":[167],"across":[168],"pathology":[169,300],"groups.":[170],"RESULTS:":[171],"frontal":[174],"interlobar":[176],"junctional":[177],"regions":[178],"less":[180,202],"likely":[181,203,214],"than":[182,216],"temporal":[183,230],"be":[186,205],"matched":[187,206,215],"(p":[188,207,219],"=":[189,193,220],".003":[190],"p":[192],".005).":[194],"from":[196],"multiple":[199],"<":[208],".001).":[209],"Tight":[210],"more":[213],"loose":[217],".013).":[221],"Cluster-resection":[222,282],"mapping":[223,283],"identified":[224],"distinct":[225],"propagation":[226],"patterns,":[227],"including":[228],"anterior-posterior":[229],"ipsilateral-contralateral":[232],"opercular":[233],"spread.":[234],"Among":[235],"49":[236],"mismatched":[237],"sampled":[239],"ICEEG,":[241],"91%":[242],"showed":[243],"interictal":[244],"discharges":[245],"63%":[247],"involved":[249],"propagation.":[252],"did":[255],"differ":[257],"pathology.":[259],"SIGNIFICANCE:":[260],"Our":[261],"findings":[262],"support":[263],"incorporating":[264],"detailed":[265],"analysis":[266],"into":[271],"refine":[275],"localization,":[277],"especially":[278],"invasive":[280],"evaluation.":[281],"patterns":[284],"may":[285],"assist":[286],"hypothesis":[288],"generation.":[289],"Matched":[290],"mild":[293],"malformation":[294],"cortical":[296],"development":[297],"negative":[299],"cases":[301],"further":[302],"highlight":[303],"MEG's":[304],"challenging":[307],"pathological":[308],"substrates.":[309]}