Gut microbiota dysbiosis shapes brain T-cell immunity in accelerated aging
showed a discordant association with the CD4⁺/CD8⁺ ratio in the brain (negative) and spleen (positive). Furthermore, CD8⁺ T cells correlated with microbiota composition variation more strongly than strain, age, and sex. Together, these findings link the gut microbiota to age-dependent immune remodeling in the brain and imply that altered microbial communities could influence pro-inflammatory T-cell responses, thereby contributing to accelerated brain aging.
Authors
- Jefferson Antônio Leite (ORCID: https://orcid.org/0000-0002-9437-5393)
- Sara Vieira‐Silva (ORCID: https://orcid.org/0000-0002-4616-7602)
- Tommy Regen (ORCID: https://orcid.org/0000-0002-7275-3330)
- Ari Waisman (ORCID: https://orcid.org/0000-0003-4304-8234)
- Vu Thu Thuy Nguyen (ORCID: https://orcid.org/0000-0002-2484-9709)
- Tinh Thi Nguyen (ORCID: https://orcid.org/0000-0003-4676-3225)
- Gwen Falony (ORCID: https://orcid.org/0000-0003-2450-0782)
- Kristina Endres (ORCID: https://orcid.org/0000-0002-1099-8287)
- Oliver Tuescher (ORCID: https://orcid.org/0000-0002-4023-5301)
- Rebecca Jasser
- Natalia Notarberardino Bos
- Yogita Kattimani
- Laura Peschke (ORCID: https://orcid.org/0009-0006-8569-9050)
- Nishada Ramphal (ORCID: https://orcid.org/0009-0008-8738-5332)
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Johannes Gutenberg University Mainz (DE)
- Leibniz Institute for Resilience Research (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Quantitative BioSciences (US)
- Institute of Medical Microbiology and Hygiene (DE)
- Institute of Communication and Computer Systems (GR)
- University Hospital in Halle (DE)
- Institute for Molecular Medicine (US)
- University of Applied Sciences Kaiserslautern (DE)
- Wageningen University & Research (NL)
Publication Details
- Journal
- Gut Microbes
- Published
- 2026-09-17
- DOI
- https://doi.org/10.1080/19490976.2026.2728329
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00