The chick embryo chorioallantoic membrane as an in vivo assay to study the skin in melanoma and other skin pathological conditions

The chick chorioallantoic membrane (CAM) is a well-established model for studying angiogenesis, tumor growth, tissue grafting, and therapeutic responses; however, conventional in ovo approaches are limited by a short experimental window, immune-related constraints, and restricted imaging accessibility. Being naturally immunodeficient, the chick embryo accepts transplantation from various tissues and species. This article analyzes the literature data concerning the use of the CAM model to study melanoma and other skin pathological conditions, due to the lack of literature data summarizing this topic.