How a Rare Inherited Lung Cancer Mutation Took Root in Appalachia

A rare inherited EGFR mutation took root in Southern Appalachia after being carried to the United States by European settlers in the 1700s. Mapping the distribution of this germline EGFRT790M variant could help clinicians identify people at elevated risk of lung cancer and target them for genetic testing and closer surveillance.

Publication Details

Journal
Cancer Discovery
Published
2026-09-17
DOI
https://doi.org/10.1158/2159-8290.cd-nw2026-0089
Primary Topic
Lung Cancer Treatments and Mutations
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
article

How a Rare Inherited Lung Cancer Mutation Took Root in Appalachia

Cancer Discovery
Lung Cancer Treatments and Mutations
article

How a Rare Inherited Lung Cancer Mutation Took Root in Appalachia

article en

Abstract

A rare inherited EGFR mutation took root in Southern Appalachia after being carried to the United States by European settlers in the 1700s. Mapping the distribution of this germline EGFRT790M variant could help clinicians identify people at elevated risk of lung cancer and target them for genetic testing and closer surveillance.

Cancer Discovery
Good health and well-being
Openalex Percentile: Top 12%
Lung Cancer Treatments and Mutations
DOISourceOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

How a Rare Inherited Lung Cancer Mutation Took Root in Appalachia · Cancer Discovery (2026) | TGRS Research Map | TGRS