Palaeoproteomic Deconvolution of Physical and Genetic Collagen Mixtures

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Publication Details

Journal
Advanced Science
Published
2026-09-16
DOI
https://doi.org/10.1002/advs.77807
Primary Topic
Pleistocene-Era Hominins and Archaeology
Type
article
Field-Weighted Citation Impact
0.00

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article

Palaeoproteomic Deconvolution of Physical and Genetic Collagen Mixtures

Maarten Dhaenens, Kévin Di Modica, Simon Daled, Dieter Deforce et al.
Advanced Science
Pleistocene-Era Hominins and Archaeology
article

Palaeoproteomic Deconvolution of Physical and Genetic Collagen Mixtures

Maarten Dhaenens, Kévin Di Modica, Simon Daled, Dieter Deforce, Jan Decher, Simon Van de Vyver, Thijs R.A. Vandenbroucke, Alexandra Burnett, Alice Toso, Grégory Abrams, Ian Engels, Tristan Dedrie, Synnøve K. Mo
article en

Abstract

Species identification in palaeoproteomics relies on genome-derived protein sequences which are often poor-quality, and lacks tools to cope with multi-species samples. Here, we address both challenges through the analysis of "physical and genetic mixtures". Species that are absent from our database are considered a "genetic mixture", i.e. a patchwork of peptides from closely related species. Inversely, various overlapping peptide stretches allow us to resolve complex "physical mixtures". This is benchmarked by analysing physical mixtures of modern bone fragments, including genetic mixtures. We illustrate the impact of our approach via a rapid and high-throughput analysis of >2500 bone fragments, revealing the Eemian-era faunal environment around Scladina Cave, including the first Palaeoloxodon antiquus identified at this site.

Advanced Science
HOGENT University of Applied Sciences and Arts (BE), University of Bonn (DE), Royal Museums of Art and History (BE), Ghent University (BE), Zoological Research Museum Alexander Koenig (DE)
Fonds Wetenschappelijk Onderzoek, Universiteit Gent, Vlaamse regering, Bijzonder Onderzoeksfonds UGent
Openalex Percentile: Top 3%
Pleistocene-Era Hominins and Archaeology
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