Plant Metabolites Screening Identifies 7‐epi‐10‐Deacetyltaxol Inhibiting Cell Division by Interfering With the Cell Cycle and Microtubule Organization

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Publication Details

Journal
Advanced Science
Published
2026-09-16
DOI
https://doi.org/10.1002/advs.77835
Primary Topic
Cancer Treatment and Pharmacology
Type
article
Field-Weighted Citation Impact
0.00

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article

Plant Metabolites Screening Identifies 7‐epi‐10‐Deacetyltaxol Inhibiting Cell Division by Interfering With the Cell Cycle and Microtubule Organization

Wen‐Hui Lin, Yu‐Tong Jiang, Baojun Yang, Yan‐Jie Zhang et al.
Advanced Science
Cancer Treatment and Pharmacology
article

Plant Metabolites Screening Identifies 7‐epi‐10‐Deacetyltaxol Inhibiting Cell Division by Interfering With the Cell Cycle and Microtubule Organization

Wen‐Hui Lin, Yu‐Tong Jiang, Baojun Yang, Yan‐Jie Zhang, W Tian, Xinxin Han, Jing-Ting Yang, Yuming Lu, Lili Jing, Xianqing Jia, Ji Wu, Qing‐Ping Yao, Yi Lü, Ying‐Xin Qi, Yu-Xuan Bai, Geng G. Tian, Ding‐Yi Lu, Ze‐Yu Xiong, Chun‐Hui Cai, Bin Zhang, Xiao‐Na Wei
article en

Abstract

Plants produce a considerable number of metabolites, and many of them appear to interfere with certain cellular processes such as cell division. For example, taxanes produced by Taxus are known as anti-cancer drugs that stabilize microtubules and prevent the cell from dividing normally. Disorder of cell division also leads to abnormal growth and development in plants. It is worthy of consideration whether these metabolites have negative effects on plants per se. In this study, we developed an efficient screening system for identifying plant metabolites affecting rapeseed seedling root growth. One compound, 7-epi-10-deacetyltaxol, inhibited tissue elongation by adversely altering cell division and elongation. And it was applied to plant cell lines, rat vascular smooth muscle cells, and human tumor organoids, resulting in similar cell division suppression. Transcriptome and proteomics analysis indicated the suppression in plant growth was through brassinosteroid-regulated expression of cell cycle proteins, while cytological observation reveals microtubule morphology anomalies. Single-nucleus transcriptome sequencing revealed inhibitory effects of ovarian cancer organoids. Together, our findings identified a universal cell division inhibitor and characterized its conserved function with respective regulatory mechanisms, providing new insights into what role "harmful" plant metabolites are playing in plants.

Advanced Science
Ministry of Education of the People's Republic of China (CN), Shanghai Jiao Tong University (CN), Peking University (CN), Collaborative Innovation Centre for Advanced Ship and Deep-Sea Exploration (CN), Ministry of Education (KR), Institute of Genetics and Developmental Biology (CN), Ningxia Medical University (CN), Viva Biotech (China) (CN), State Key Laboratory of Plant Cell and Chromosome Engineering
National Natural Science Foundation of China
Openalex Percentile: Top 14%
Cancer Treatment and Pharmacology
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