Precise resistance training alleviates osteosarcopenia via the GLP-1/myostatin path: a 32-week randomized controlled trial and molecular mechanism study

{"BACKGROUND:":[0],"With":[1],"the":[2,5,22,76,90,117,135,144],"ageing":[3],"of":[4,28,92,140],"global":[6],"population,":[7],"osteoporosis":[8,42],"poses":[9],"a":[10,64],"serious":[11],"challenge":[12],"to":[13,20],"elderly":[14,50,141],"health.":[15],"PURPOSE:":[16],"The":[17],"aim":[18],"is":[19,86],"explore":[21],"intervention":[23,58,154],"effect":[24],"and":[25,63,116,138],"molecular":[26],"mechanism":[27],"resistance":[29,130],"training":[30,131],"(RT)":[31],"based":[32],"on":[33,38],"precise":[34],"mechanical":[35],"load":[36],"monitoring":[37],"patients":[39,142],"with":[40,44,89],"primary":[41],"complicated":[43],"muscle":[45,107,157],"atrophy.":[46,158],"METHODS:":[47],"Recruiting":[48],"98":[49],"patients,":[51],"they":[52],"were":[53],"randomly":[54],"divided":[55],"into":[56],"an":[57],"group":[59,66],"(n":[60,67],"=":[61,68],"49)":[62],"control":[65],"49).":[69],"Molecular":[70],"level":[71],"studies":[72],"have":[73],"confirmed":[74],"that":[75,102],"increase":[77],"in":[78,114,155],"endogenous":[79],"GLP-1":[80,118],"secretion":[81],"induced":[82],"by":[83,109],"RT":[84],"(+46.9%)":[85],"significantly":[87],"correlated":[88],"downregulation":[91],"MSTN":[93,103],"expression":[94],"(-41.7%).":[95],"RESULTS:":[96],"In":[97],"vitro":[98],"experiments":[99],"further":[100],"elucidated":[101],"mature":[104],"peptides":[105],"inhibit":[106],"regeneration":[108],"inducing":[110],"G2/M":[111],"phase":[112],"blockade":[113,126],"myoblasts,":[115],"mediated":[119],"signalling":[120],"pathway":[121],"can":[122],"effectively":[123],"alleviate":[124],"this":[125],"effect.":[127],"CONCLUSION:":[128],"Precise":[129],"has":[132],"synergistically":[133],"improved":[134],"musculoskeletal":[136],"structure":[137],"function":[139],"through":[143],"\\"GLP-1/MSTN":[145],"axis\\",":[146],"providing":[147],"important":[148],"biological":[149],"evidence":[150],"for":[151],"clinical":[152],"precision":[153],"skeletal":[156]}