Deciphering senescence-associated mechanisms through cell painting & transcriptomics
Senescence is a key pathomechanism across chronic diseases but also highly heterogeneous. In this study, we demonstrate that high-content imaging and transcriptomics can jointly shed light on senescence in vitro, distinguishing replicative and chemically induced senescence, differentiating from quiescence and characterizing the senolytic response.
Authors
- Patrik Erlmann
- Anika Liu (ORCID: https://orcid.org/0000-0002-8561-4700)
- Yuliana Tan (ORCID: https://orcid.org/0000-0002-5923-2215)
- Stefano Patassini (ORCID: https://orcid.org/0000-0002-9597-6430)
- Revati Wani (ORCID: https://orcid.org/0000-0002-8980-5969)
- Alec Dick
- Emily Larkin
Institutions
- Boehringer Ingelheim (Germany) (DE)
- Howard Hughes Medical Institute (US)
- Boehringer Ingelheim (Egypt) (EG)
Publication Details
- Journal
- npj Aging
- Published
- 2026-09-17
- DOI
- https://doi.org/10.1038/s41514-026-00500-8
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00