Pathological Signal‐Responsive Nanoplatforms for Sepsis: Integrating Biomarker Sensing With Spatiotemporal Drug Delivery and Immunomodulation

{"Sepsis":[0],"remains":[1],"a":[2,24],"life-threatening":[3],"syndrome":[4],"characterized":[5],"by":[6,106,167],"dynamic":[7],"immune":[8],"dysregulation":[9],"and":[10,51,84,95,129,149],"multi-organ":[11],"failure.":[12],"Stimulus-responsive":[13],"nanoplatforms,":[14],"which":[15],"function":[16],"as":[17,23,43],"\\"biomarker-triggered\\"":[18],"therapeutic":[19,68,104],"systems,":[20],"have":[21],"emerged":[22],"frontier":[25],"in":[26,45,70,122],"precision":[27,174],"sepsis":[28,41,165],"management.":[29],"These":[30,158],"platforms":[31,102,152],"are":[32],"engineered":[33],"to":[34,153,163,172],"autonomously":[35],"sense":[36],"pathological":[37],"hallmarks":[38],"within":[39],"the":[40,80,119,130,141,161],"microenvironment-such":[42],"fluctuations":[44],"pH,":[46],"reactive":[47],"oxygen":[48],"species":[49],"(ROS),":[50],"specific":[52],"enzymatic":[53],"over-expression-thereby":[54],"enabling":[55],"precise,":[56],"spatiotemporal":[57],"drug":[58,109],"release.":[59],"Unlike":[60],"conventional":[61],"static":[62],"therapies,":[63],"these":[64,101],"\\"smart\\"":[65],"nanoplatforms":[66,87],"modulate":[67],"intervention":[69],"real-time":[71,144],"based":[72],"on":[73],"disease":[74],"progression.":[75],"This":[76],"review":[77],"comprehensively":[78],"evaluates":[79],"integration":[81],"of":[82,132,143],"sensing":[83],"therapy":[85],"using":[86],"loaded":[88],"with":[89],"antibiotics,":[90],"antimicrobial":[91],"peptides,":[92],"anti-inflammatory":[93],"agents,":[94],"gene-regulatory":[96],"molecules.":[97],"We":[98],"highlight":[99],"how":[100],"optimize":[103],"windows":[105],"enhancing":[107],"local":[108],"bioavailability":[110],"while":[111],"minimizing":[112],"systemic":[113],"off-target":[114],"toxicity.":[115],"Furthermore,":[116],"we":[117,136],"discuss":[118],"current":[120],"hurdles":[121],"clinical":[123],"translation,":[124],"including":[125],"patient-specific":[126],"biomarker":[127],"variability":[128],"complexity":[131],"scalable":[133],"fabrication.":[134],"Finally,":[135],"propose":[137],"future":[138],"directions,":[139],"emphasizing":[140],"synergy":[142],"biosensing,":[145],"artificial":[146],"intelligence":[147],"(AI),":[148],"multimodal":[150],"\\"theranostic\\"":[151],"achieve":[154],"stage-specific,":[155],"personalized":[156],"interventions.":[157],"advancements":[159],"hold":[160],"potential":[162],"redefine":[164],"management":[166],"shifting":[168],"from":[169],"\\"one-size-fits-all\\"":[170],"treatments":[171],"biomarker-driven":[173],"medicine.":[175]}

Authors

Institutions

Publication Details

Journal
Advanced Science
Published
2026-09-16
DOI
https://doi.org/10.1002/advs.77718
Primary Topic
Nanoplatforms for cancer theranostics
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
article

Pathological Signal‐Responsive Nanoplatforms for Sepsis: Integrating Biomarker Sensing With Spatiotemporal Drug Delivery and Immunomodulation

Xuan Zhao, Yu-Chang Wang, Kang Wang, Yukun Liu et al.
Advanced Science
Nanoplatforms for cancer theranostics
article

Pathological Signal‐Responsive Nanoplatforms for Sepsis: Integrating Biomarker Sensing With Spatiotemporal Drug Delivery and Immunomodulation

Xuan Zhao, Yu-Chang Wang, Kang Wang, Yukun Liu, Xiangjun Bai, Kwet Kyawl Yan, Zhikai Xu, Zhanfei Li
article en

Abstract

Sepsis remains a life-threatening syndrome characterized by dynamic immune dysregulation and multi-organ failure. Stimulus-responsive nanoplatforms, which function as "biomarker-triggered" therapeutic systems, have emerged as a frontier in precision sepsis management. These platforms are engineered to autonomously sense pathological hallmarks within the sepsis microenvironment-such as fluctuations in pH, reactive oxygen species (ROS), and specific enzymatic over-expression-thereby enabling precise, spatiotemporal drug release. Unlike conventional static therapies, these "smart" nanoplatforms modulate therapeutic intervention in real-time based on disease progression. This review comprehensively evaluates the integration of sensing and therapy using nanoplatforms loaded with antibiotics, antimicrobial peptides, anti-inflammatory agents, and gene-regulatory molecules. We highlight how these platforms optimize therapeutic windows by enhancing local drug bioavailability while minimizing systemic off-target toxicity. Furthermore, we discuss the current hurdles in clinical translation, including patient-specific biomarker variability and the complexity of scalable fabrication. Finally, we propose future directions, emphasizing the synergy of real-time biosensing, artificial intelligence (AI), and multimodal "theranostic" platforms to achieve stage-specific, personalized interventions. These advancements hold the potential to redefine sepsis management by shifting from "one-size-fits-all" treatments to biomarker-driven precision medicine.

Advanced Science
German Institute for Disaster Medicine (DE), Tongji Hospital (CN), Huazhong University of Science and Technology (CN)
National Natural Science Foundation of China, Huazhong University of Science and Technology, Natural Science Foundation of Hubei Province, Tongji University, Tongji Medical College, Huazhong University of Science and Technology
Openalex Percentile: Top 21%
Nanoplatforms for cancer theranostics
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.