Prolonged Transcortical Mixed Aphasia Following Awake Glioma Resection: Functional Language Network Disruption Associated with Persistent Epileptiform Activity
Aphasia occurring after tumor resection in the language-dominant hemisphere is commonly interpreted as a consequence of irreversible structural injury. In awake craniotomy, intraoperative language mapping enables real-time functional monitoring and is expected to reduce the risk of postoperative aphasia. However, postoperative language impairment is not always attributable to structural damage alone, and functional network disturbances may also contribute.
Authors
- Ayumi Sakata
- Kazuhisa Kuwabara
- Masako Fujise
- Koji Yoshimoto (ORCID: https://orcid.org/0000-0001-7912-2024)
- Nobutaka Mukae (ORCID: https://orcid.org/0000-0003-1990-1485)
- Yutaka Fujioka (ORCID: https://orcid.org/0000-0002-8506-9343)
- Ryusuke Hatae (ORCID: https://orcid.org/0000-0001-5636-8064)
- Hiroshi Shigeto (ORCID: https://orcid.org/0000-0001-5437-943X)
- Eriko Watanabe (ORCID: https://orcid.org/0000-0003-4220-9710)
- Masayuki Yanagida
- Minako Kawaguchi
- Taisei YAMADA
Institutions
- Kyushu University (JP)
- Kyushu University Hospital (JP)
- Department of Medical Sciences (BY)
Publication Details
- Journal
- NMC Case Report Journal
- Published
- 2026-09-16
- DOI
- https://doi.org/10.2176/jns-nmc.2026-0122
- Primary Topic
- Neurobiology of Language and Bilingualism
- Type
- article
- Field-Weighted Citation Impact
- 0.00