FlyBase: Development and metamorphosis into the Alliance
FlyBase (flybase.org) is an openly accessible, centralized resource for genetic, genomic and functional data about Drosophila melanogaster. This article describes recent updates to the curation and display of expression, functional and reagent data within FlyBase, including the incorporation of long-read RNA-seq data, the introduction of the 'Gene ToolKit' for identifying key genetic reagents, and new reports for protein complexes, metabolic pathways and combinations of split-GAL4 drivers. We also provide information on changes to our data archiving policy and guidance on how best to use AI methods to interrogate FlyBase. Finally, we give an update on the status of transitioning FlyBase into the Alliance of Genome Resources.
Authors
- Nick Brown (ORCID: https://orcid.org/0009-0006-4083-7579)
- Arzu Öztürk‐Çolak (ORCID: https://orcid.org/0000-0002-8116-217X)
- Steven J Marygold (ORCID: https://orcid.org/0000-0003-2759-266X)
- Helen L. Attrill (ORCID: https://orcid.org/0000-0003-3212-6364)
- Alex D. McLachlan (ORCID: https://orcid.org/0000-0002-5214-8125)
- Clare Pilgrim (ORCID: https://orcid.org/0000-0002-1373-1705)
- Mark Zytkovicz
- Damien Goutte-Gattat (ORCID: https://orcid.org/0000-0002-6095-8718)
- Giulia Antonazzo (ORCID: https://orcid.org/0000-0003-0086-5621)
- Pinglei Zhou
- Victor B. Strelets (ORCID: https://orcid.org/0000-0001-6556-9335)
- Rossana Zaru (ORCID: https://orcid.org/0000-0002-3358-4423)
- Gillian Millburn (ORCID: https://orcid.org/0000-0002-1139-1145)
- Susan Russo Gelbart
- L. Sian Gramates (ORCID: https://orcid.org/0000-0002-6700-3797)
- Norbert Perrimon (ORCID: https://orcid.org/0000-0001-7542-472X)
- Katja Röper (ORCID: https://orcid.org/0000-0002-3361-766X)
- Christopher J. Tabone (ORCID: https://orcid.org/0000-0001-8746-0680)
- Richard M. Cripps (ORCID: https://orcid.org/0000-0001-6565-285X)
- Aoife Larkin (ORCID: https://orcid.org/0000-0003-4970-5901)
- Kris Broll
- Jolene Seme
- Ian Longden
- TyAnna L. Lovato
- Madeline A. Crosby
- Gilberto dos Santos
- Alex McLachlan
- Helen Attrill
- Gillian Millburn
- Thom Kaufman
- Jim Thurmond
- Beverley Matthews
- Brian Calvi
- Sian Gramates
- Victoria Jenkins
- Seth Campbell
Institutions
- Harvard University (US)
- University of Cambridge (GB)
- Jackson Laboratory (US)
Publication Details
- Journal
- Genetics
- Published
- 2026-10-26
- DOI
- https://doi.org/10.1093/genetics/iyag247
- Primary Topic
- Genomics and Phylogenetic Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- National Institutes of Health
- Medical Research Council
- National Human Genome Research Institute
- National Institute of Diabetes and Digestive and Kidney Diseases