Concurrent excitation and detection in magnetic resonance using voltage-controlled oscillators

Dead time following radio frequency excitation limits pulsed magnetic resonance (MR) experiments by obscuring early-time spin dynamics and short-lived signals. We demonstrate continuous concurrent excitation and detection using two oscillator-based MR detectors: a high-frequency (477 megahertz) injection-locked voltage-controlled oscillator (VCO) array enabling a scalable segmented-coil architecture and a low-frequency (17 megahertz) single-coil VCO. Both detectors are embedded in custom-designed phase-locked loops, enabling phase-coherent multipulse operation. Using a planar segmented coil driven by a chip-integrated VCO array operating at 477-megahertz proton frequency, we perform conventional Fourier transform nuclear MR, continuously monitor driven Rabi oscillations throughout the excitation pulse, and observe the immediate onset of free-induction decay, all without dedicated transmit-receive switches or receiver gating. We further demonstrate phase-coherent, phase-cycled multipulse operation, including a Hahn echo sequence realized on a second system operating at 17 megahertz. Together, these results demonstrate the general applicability and versatility of the oscillator-based detection principle across pulse sequences and operating frequencies.

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Publication Details

Journal
Science Advances
Published
2026-09-16
DOI
https://doi.org/10.1126/sciadv.aeg6581
Primary Topic
Advanced NMR Techniques and Applications
Type
article
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article

Concurrent excitation and detection in magnetic resonance using voltage-controlled oscillators

Michal Kern, K. Lips, Klaus Scheffler, Jens Anders et al.
Science Advances
Advanced NMR Techniques and Applications
article

Concurrent excitation and detection in magnetic resonance using voltage-controlled oscillators

Michal Kern, K. Lips, Klaus Scheffler, Jens Anders, Bernhard Bluemich, Katja Drerup, Felix Schuderer, Samuel Wazynski, Qing Yang, Weiyi Zhang, Zhibin Zhao
article en

Abstract

Dead time following radio frequency excitation limits pulsed magnetic resonance (MR) experiments by obscuring early-time spin dynamics and short-lived signals. We demonstrate continuous concurrent excitation and detection using two oscillator-based MR detectors: a high-frequency (477 megahertz) injection-locked voltage-controlled oscillator (VCO) array enabling a scalable segmented-coil architecture and a low-frequency (17 megahertz) single-coil VCO. Both detectors are embedded in custom-designed phase-locked loops, enabling phase-coherent multipulse operation. Using a planar segmented coil driven by a chip-integrated VCO array operating at 477-megahertz proton frequency, we perform conventional Fourier transform nuclear MR, continuously monitor driven Rabi oscillations throughout the excitation pulse, and observe the immediate onset of free-induction decay, all without dedicated transmit-receive switches or receiver gating. We further demonstrate phase-coherent, phase-cycled multipulse operation, including a Hahn echo sequence realized on a second system operating at 17 megahertz. Together, these results demonstrate the general applicability and versatility of the oscillator-based detection principle across pulse sequences and operating frequencies.

Science AdvancesVol. 12(38)
University of Stuttgart (DE), Karlsruhe Institute of Technology (DE), Helmholtz-Zentrum Berlin für Materialien und Energie (DE), Max Planck Institute for Biological Cybernetics (DE), Institut für Mikroelektronik Stuttgart (DE), Freie Universität Berlin (DE), University of Tübingen (DE), RWTH Aachen University (DE)
Affordable and clean energy
Openalex Percentile: Top 21%
Advanced NMR Techniques and Applications
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