Concurrent excitation and detection in magnetic resonance using voltage-controlled oscillators
Dead time following radio frequency excitation limits pulsed magnetic resonance (MR) experiments by obscuring early-time spin dynamics and short-lived signals. We demonstrate continuous concurrent excitation and detection using two oscillator-based MR detectors: a high-frequency (477 megahertz) injection-locked voltage-controlled oscillator (VCO) array enabling a scalable segmented-coil architecture and a low-frequency (17 megahertz) single-coil VCO. Both detectors are embedded in custom-designed phase-locked loops, enabling phase-coherent multipulse operation. Using a planar segmented coil driven by a chip-integrated VCO array operating at 477-megahertz proton frequency, we perform conventional Fourier transform nuclear MR, continuously monitor driven Rabi oscillations throughout the excitation pulse, and observe the immediate onset of free-induction decay, all without dedicated transmit-receive switches or receiver gating. We further demonstrate phase-coherent, phase-cycled multipulse operation, including a Hahn echo sequence realized on a second system operating at 17 megahertz. Together, these results demonstrate the general applicability and versatility of the oscillator-based detection principle across pulse sequences and operating frequencies.
Authors
- Michal Kern (ORCID: https://orcid.org/0000-0001-9376-4568)
- K. Lips (ORCID: https://orcid.org/0000-0003-4691-7239)
- Klaus Scheffler (ORCID: https://orcid.org/0000-0001-6316-8773)
- Jens Anders (ORCID: https://orcid.org/0000-0002-2498-0352)
- Bernhard Bluemich (ORCID: https://orcid.org/0000-0002-1152-4438)
- Katja Drerup
- Felix Schuderer
- Samuel Wazynski
- Qing Yang
- Weiyi Zhang (ORCID: https://orcid.org/0009-0009-3011-1135)
- Zhibin Zhao (ORCID: https://orcid.org/0009-0007-4660-0211)
Institutions
- University of Stuttgart (DE)
- Karlsruhe Institute of Technology (DE)
- Helmholtz-Zentrum Berlin für Materialien und Energie (DE)
- Max Planck Institute for Biological Cybernetics (DE)
- Institut für Mikroelektronik Stuttgart (DE)
- Freie Universität Berlin (DE)
- University of Tübingen (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Science Advances
- Published
- 2026-09-16
- DOI
- https://doi.org/10.1126/sciadv.aeg6581
- Primary Topic
- Advanced NMR Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00