Chitosan activates a sequential Ca 2+ -ROS-NO-jasmonate signaling cascade governing withanolide accumulation in Withania somnifera
, with signaling dynamics predicting metabolic output. This pharmacological asymmetry provides strong directional evidence for pathway ordering, but it does not constitute definitive molecular proof of causality because inhibitor specificity is incomplete and no genetic or rescue experiment was performed.
Authors
- Aqib Mahmood (ORCID: https://orcid.org/0000-0002-7752-5185)
- Azatullah Zaheer
- Imran Haider (ORCID: https://orcid.org/0000-0002-0100-2513)
- Muhammad Yousaf Nadeem (ORCID: https://orcid.org/0000-0002-9942-5230)
- Abdullah R. Alanzi
- Rashed N. Herqash (ORCID: https://orcid.org/0000-0002-4502-9507)
- Omar M. Noman
- Sana ur Rehman
- Shazia Perveen
Institutions
- Nanjing Agricultural University (CN)
- Islamia University of Bahawalpur (PK)
- King Saud University (SA)
- Salam University (AF)
- National Centre for Social research (GR)
- The Women University Multan (PK)
- All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (RU)
- Da Nang University of Economics (VN)
- Nakhchivan State University (AZ)
- College of Business Administration (LV)
Publication Details
- Journal
- Plant Signaling & Behavior
- Published
- 2026-09-16
- DOI
- https://doi.org/10.1080/15592324.2026.2733235
- Primary Topic
- Phytochemicals and Medicinal Plants
- Type
- article
- Field-Weighted Citation Impact
- 0.00