Communicating Parkinson Risk in Affordable Remote Assessment: Natural Frequencies, Uncertainty and Follow-Up Decisions

Abstract An inexpensive remote assessment can still create confusion and household expense if a probability is mistaken for a diagnosis or a concerning result lacks an affordable follow-up route. This methods perspective develops a communication framework for Parkinson-related risk information using targeted narrative evidence and original numerical illustrations. The framework distinguishes current-condition classification, future-event risk, model confidence and referral thresholds. In a hypothetical group of 1,000 people with 5% target-condition prevalence, 80% sensitivity and 90% specificity, 135 results are positive but only 40 occur among people with the target condition. Presenting the resulting 29.6% positive predictive value through nested frequencies makes the denominator explicit without establishing that the display improves comprehension. A second illustration contrasts five-year probabilities of 3% and 6%: the difference is three percentage points or 30 additional events per 1,000, while the relative increase is 100%. These values are pedagogical assumptions, not Parkinson risk estimates or treatment effects. Recent evidence on disclosure preferences and visual proportion judgments informs a proposed evaluation of understanding, emotional response, decision quality and financial access. Patient affordability includes the direct payments needed to clarify an uncertain result and obtain appropriate care, not only the price of the initial assessment. The paper proposes consistent denominators, explicit time horizons, optional layered explanation and measured comprehension. Clear communication requires prospective testing with intended users; natural frequencies, icons and concise wording should not be assumed to work equally well for everyone. No communication trial or current NeuralCipher clinical performance is reported. Article details NeuralCipherai; Kadir Tamrak; Salih Yaldız; Feride Yaldız; Ömer Ağyol; Yavuz Selim Silay; Hasan Randa Methods perspective with selected narrative evidence and transparent quantitative analysis A communication-evaluation framework with reproducible nested-frequency and absolute-risk illustrations, proposed comprehension questions and patient-payment outcomes. Project: NeuralCipher. Bibliographic records are supplied in BibTeX and RIS formats for reference-management software, including Zotero. Reproducible calculations and figure data accompany the article. References Berg, D., Postuma, R. B., Adler, C. H., Bloem, B. R., Chan, P., Dubois, B., Gasser, T., Goetz, C. G., Halliday, G., Joseph, L., Lang, A. E., Liepelt‐Scarfone, I., Litvan, I., Marek, K., Obeso, J., Oertel, W., Olanow, C. W., Poewe, W., Stern, M., & Deuschl, G. (2015). MDS research criteria for prodromal Parkinson's disease. Movement Disorders, 30(12), 1600–1611. https://doi.org/10.1002/mds.26431 Canoro, V., Pilotto, A., Lena, F., Fioravanti, V., Longo, C., Schirinzi, T., Picillo, M., Pellecchia, M. T., Sorrentino, C., Cavallieri, F., Padovani, A., Malaguti, M. C., Modugno, N., Barone, P., & Erro, R. (2025). Digital Inclusion in Parkinson's Disease: A Case–Control Study. Movement Disorders Clinical Practice, 12(11), 1873-1881. https://doi.org/10.1002/mdc3.70171 Carling, C. L. L., Kristoffersen, D. T., Montori, V. M., Herrin, J., Schünemann, H. J., Treweek, S., Akl, E. A., & Oxman, A. D. (2009). The effect of alternative summary statistics for communicating risk reduction on decisions about taking statins: A randomized trial. PLoS Medicine, 6(8), e1000134. https://doi.org/10.1371/journal.pmed.1000134 Collins, G. S., Moons, K. G. M., Dhiman, P., Riley, R. D., Beam, A. L., Van Calster, B., Ghassemi, M., Liu, X., Reitsma, J. B., van Smeden, M., Boulesteix, A.-L., Camaradou, J. C., Celi, L. A., Denaxas, S., Denniston, A. K., Glocker, B., Golub, R. M., Harvey, H., Heinze, G., . . . Logullo, P. (2024). TRIPOD+AI statement: Updated guidance for reporting clinical prediction models that use regression or machine learning methods. BMJ, 385, Article e078378. https://doi.org/10.1136/bmj-2023-078378 Galesic, M., Garcia-Retamero, R., & Gigerenzer, G. (2009). Using icon arrays to communicate medical risks: Overcoming low numeracy. Health Psychology, 28(2), 210-216. https://doi.org/10.1037/a0014474 Gigerenzer, G., & Hoffrage, U. (1995). How to improve Bayesian reasoning without instruction: Frequency formats. Psychological Review, 102(4), 684-704. https://doi.org/10.1037/0033-295X.102.4.684 Heinzel, S., Berg, D., Gasser, T., Chen, H., Yao, C., Postuma, R. B., & the MDS Task Force on the Definition of Parkinson's Disease. (2019). Update of the MDS research criteria for prodromal Parkinson's disease. Movement Disorders, 34(10), 1464–1470. https://doi.org/10.1002/mds.27802 Hoffrage, U., & Gigerenzer, G. (1998). Using natural frequencies to improve diagnostic inferences. Academic Medicine, 73(5), 538–540. https://doi.org/10.1097/00001888-199805000-00024 Husereau, D., Drummond, M., Augustovski, F., de Bekker-Grob, E., Briggs, A. H., Carswell, C., Caulley, L., Chaiyakunapruk, N., Greenberg, D., Loder, E., Mauskopf, J., Mullins, C. D., Petrou, S., Pwu, R. F., Staniszewska, S., & CHEERS 2022 ISPOR Good Research Practices Task Force. (2022). Consolidated Health Economic Evaluation Reporting Standards 2022 (CHEERS 2022) statement: Updated reporting guidance for health economic evaluations. BMJ, 376, e067975. https://doi.org/10.1136/bmj-2021-067975 Lipkus, I. M., Samsa, G., & Rimer, B. K. (2001). General performance on a numeracy scale among highly educated samples. Medical Decision Making, 21(1), 37-44. https://doi.org/10.1177/0272989X0102100105 Mahlknecht, P., Leiter, S., Horlings, C., Schwarzová, K., Egner, I., Stockner, H., Marini, K., Theyer, C., Zamarian, L., Djamshidian, A., Seppi, K., Farfan, F., Garrido, A., Ghosh, S., Krüger, R., McIntyre, D., Mollenhauer, B., Noyce, A., Pauly, C., . . . the HeBA Consortium. (2025). Preferences regarding disclosure of risk for Parkinson's disease in a population-based study. Movement Disorders Clinical Practice, 12(2), 203-209. https://doi.org/10.1002/mdc3.14264 Markant, D. B. (2026). Asymmetric shape variability biases proportion judgments with icon arrays. Cognitive Science, 50(5), e70227. https://doi.org/10.1111/cogs.70227 Moons, K. G. M., Damen, J. A. A., Kaul, T., Hooft, L., Andaur Navarro, C., Dhiman, P., Beam, A. L., Van Calster, B., Celi, L. A., Denaxas, S., Denniston, A. K., Ghassemi, M., Heinze, G., Kengne, A. P., Maier-Hein, L., Liu, X., Logullo, P., McCradden, M. D., Liu, N., . . . van Smeden, M. (2025). PROBAST+AI: An updated quality, risk of bias, and applicability assessment tool for prediction models using regression or artificial intelligence methods. BMJ, 388, Article e082505. https://doi.org/10.1136/bmj-2024-082505 Postuma, R. B., Berg, D., Stern, M., Poewe, W., Olanow, C. W., Oertel, W., Obeso, J., Marek, K., Litvan, I., Lang, A. E., Halliday, G., Goetz, C. G., Gasser, T., Dubois, B., Chan, P., Bloem, B. R., Adler, C. H., & Deuschl, G. (2015). MDS clinical diagnostic criteria for Parkinson's disease. Movement Disorders, 30(12), 1591–1601. https://doi.org/10.1002/mds.26424 Postuma, R. B., Iranzo, A., Hu, M., Högl, B., Boeve, B. F., Manni, R., Oertel, W. H., Arnulf, I., Ferini-Strambi, L., Puligheddu, M., Antelmi, E., Cochen De Cock, V., Arnaldi, D., Mollenhauer, B., Videnovic, A., Sonka, K., Jung, K.-Y., Kunz, D., Dauvilliers, Y., . . . Pelletier, A. (2019). Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: A multicentre study. Brain, 142(3), 744–759. https://doi.org/10.1093/brain/awz030 Ruiz, J. G., Andrade, A. D., Garcia-Retamero, R., Anam, R., Rodriguez, R., & Sharit, J. (2013). Communicating global cardiovascular risk: Are icon arrays better than numerical estimates in improving understanding, recall and perception of risk? Patient Education and Counseling, 93(3), 394-402. https://doi.org/10.1016/j.pec.2013.06.026 Sanders, G. D., Neumann, P. J., Basu, A., Brock, D. W., Feeny, D., Krahn, M., Kuntz, K. M., Meltzer, D. O., Owens, D. K., Prosser, L. A., Salomon, J. A., Sculpher, M. J., Trikalinos, T. A., Russell, L. B., Siegel, J. E., & Ganiats, T. G. (2016). Recommendations for Conduct, Methodological Practices, and Reporting of Cost-effectiveness Analyses: Second Panel on Cost-Effectiveness in Health and Medicine. JAMA, 316(10), 1093–1103. https://doi.org/10.1001/jama.2016.12195 Schwartz, L. M., Woloshin, S., Black, W. C., & Welch, H. G. (1997). The role of numeracy in understanding the benefit of screening mammography. Annals of Internal Medicine, 127(11), 966-972. https://doi.org/10.7326/0003-4819-127-11-199712010-00003 Van Calster, B., McLernon, D. J., van Smeden, M., Wynants, L., Steyerberg, E. W., & On behalf of Topic Group ‘Evaluating diagnostic tests and prediction models’ of the STRATOS initiative. (2019). Calibration: The Achilles heel of predictive analytics. BMC Medicine, 17(1), Article 230. https://doi.org/10.1186/s12916-019-1466-7 Vickers, A. J., & Elkin, E. B. (2006). Decision curve analysis: A novel method for evaluating prediction models. Medical Decision Making, 26(6), 565–574. https://doi.org/10.1177/0272989x06295361

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Zenodo (CERN European Organization for Nuclear Research)
Published
2026-09-16
DOI
https://doi.org/10.5281/zenodo.22782524
Primary Topic
Parkinson's Disease Mechanisms and Treatments
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preprint
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preprint

Communicating Parkinson Risk in Affordable Remote Assessment: Natural Frequencies, Uncertainty and Follow-Up Decisions

Feride Yaldiz, Yavuz Selim Sılay, Kadir Tamrak, Salih Yaldız et al.
Zenodo (CERN European Organization for Nuclear Research)
Parkinson's Disease Mechanisms and Treatments
preprint

Communicating Parkinson Risk in Affordable Remote Assessment: Natural Frequencies, Uncertainty and Follow-Up Decisions

Feride Yaldiz, Yavuz Selim Sılay, Kadir Tamrak, Salih Yaldız, NeuralCipherai, Hasan Randa, Ömer Ağyol
preprint en

Abstract

Abstract An inexpensive remote assessment can still create confusion and household expense if a probability is mistaken for a diagnosis or a concerning result lacks an affordable follow-up route. This methods perspective develops a communication framework for Parkinson-related risk information using targeted narrative evidence and original numerical illustrations. The framework distinguishes current-condition classification, future-event risk, model confidence and referral thresholds. In a hypothetical group of 1,000 people with 5% target-condition prevalence, 80% sensitivity and 90% specificity, 135 results are positive but only 40 occur among people with the target condition. Presenting the resulting 29.6% positive predictive value through nested frequencies makes the denominator explicit without establishing that the display improves comprehension. A second illustration contrasts five-year probabilities of 3% and 6%: the difference is three percentage points or 30 additional events per 1,000, while the relative increase is 100%. These values are pedagogical assumptions, not Parkinson risk estimates or treatment effects. Recent evidence on disclosure preferences and visual proportion judgments informs a proposed evaluation of understanding, emotional response, decision quality and financial access. Patient affordability includes the direct payments needed to clarify an uncertain result and obtain appropriate care, not only the price of the initial assessment. The paper proposes consistent denominators, explicit time horizons, optional layered explanation and measured comprehension. Clear communication requires prospective testing with intended users; natural frequencies, icons and concise wording should not be assumed to work equally well for everyone. No communication trial or current NeuralCipher clinical performance is reported. Article details NeuralCipherai; Kadir Tamrak; Salih Yaldız; Feride Yaldız; Ömer Ağyol; Yavuz Selim Silay; Hasan Randa Methods perspective with selected narrative evidence and transparent quantitative analysis A communication-evaluation framework with reproducible nested-frequency and absolute-risk illustrations, proposed comprehension questions and patient-payment outcomes. Project: NeuralCipher. Bibliographic records are supplied in BibTeX and RIS formats for reference-management software, including Zotero. Reproducible calculations and figure data accompany the article. References Berg, D., Postuma, R. B., Adler, C. H., Bloem, B. R., Chan, P., Dubois, B., Gasser, T., Goetz, C. G., Halliday, G., Joseph, L., Lang, A. E., Liepelt‐Scarfone, I., Litvan, I., Marek, K., Obeso, J., Oertel, W., Olanow, C. W., Poewe, W., Stern, M., & Deuschl, G. (2015). MDS research criteria for prodromal Parkinson's disease. Movement Disorders, 30(12), 1600–1611. https://doi.org/10.1002/mds.26431 Canoro, V., Pilotto, A., Lena, F., Fioravanti, V., Longo, C., Schirinzi, T., Picillo, M., Pellecchia, M. T., Sorrentino, C., Cavallieri, F., Padovani, A., Malaguti, M. C., Modugno, N., Barone, P., & Erro, R. (2025). Digital Inclusion in Parkinson's Disease: A Case–Control Study. Movement Disorders Clinical Practice, 12(11), 1873-1881. https://doi.org/10.1002/mdc3.70171 Carling, C. L. L., Kristoffersen, D. T., Montori, V. M., Herrin, J., Schünemann, H. J., Treweek, S., Akl, E. A., & Oxman, A. D. (2009). The effect of alternative summary statistics for communicating risk reduction on decisions about taking statins: A randomized trial. PLoS Medicine, 6(8), e1000134. https://doi.org/10.1371/journal.pmed.1000134 Collins, G. S., Moons, K. G. M., Dhiman, P., Riley, R. D., Beam, A. L., Van Calster, B., Ghassemi, M., Liu, X., Reitsma, J. B., van Smeden, M., Boulesteix, A.-L., Camaradou, J. C., Celi, L. A., Denaxas, S., Denniston, A. K., Glocker, B., Golub, R. M., Harvey, H., Heinze, G., . . . Logullo, P. (2024). TRIPOD+AI statement: Updated guidance for reporting clinical prediction models that use regression or machine learning methods. BMJ, 385, Article e078378. https://doi.org/10.1136/bmj-2023-078378 Galesic, M., Garcia-Retamero, R., & Gigerenzer, G. (2009). Using icon arrays to communicate medical risks: Overcoming low numeracy. Health Psychology, 28(2), 210-216. https://doi.org/10.1037/a0014474 Gigerenzer, G., & Hoffrage, U. (1995). How to improve Bayesian reasoning without instruction: Frequency formats. Psychological Review, 102(4), 684-704. https://doi.org/10.1037/0033-295X.102.4.684 Heinzel, S., Berg, D., Gasser, T., Chen, H., Yao, C., Postuma, R. B., & the MDS Task Force on the Definition of Parkinson's Disease. (2019). Update of the MDS research criteria for prodromal Parkinson's disease. Movement Disorders, 34(10), 1464–1470. https://doi.org/10.1002/mds.27802 Hoffrage, U., & Gigerenzer, G. (1998). Using natural frequencies to improve diagnostic inferences. Academic Medicine, 73(5), 538–540. https://doi.org/10.1097/00001888-199805000-00024 Husereau, D., Drummond, M., Augustovski, F., de Bekker-Grob, E., Briggs, A. H., Carswell, C., Caulley, L., Chaiyakunapruk, N., Greenberg, D., Loder, E., Mauskopf, J., Mullins, C. D., Petrou, S., Pwu, R. F., Staniszewska, S., & CHEERS 2022 ISPOR Good Research Practices Task Force. (2022). Consolidated Health Economic Evaluation Reporting Standards 2022 (CHEERS 2022) statement: Updated reporting guidance for health economic evaluations. BMJ, 376, e067975. https://doi.org/10.1136/bmj-2021-067975 Lipkus, I. M., Samsa, G., & Rimer, B. K. (2001). General performance on a numeracy scale among highly educated samples. Medical Decision Making, 21(1), 37-44. https://doi.org/10.1177/0272989X0102100105 Mahlknecht, P., Leiter, S., Horlings, C., Schwarzová, K., Egner, I., Stockner, H., Marini, K., Theyer, C., Zamarian, L., Djamshidian, A., Seppi, K., Farfan, F., Garrido, A., Ghosh, S., Krüger, R., McIntyre, D., Mollenhauer, B., Noyce, A., Pauly, C., . . . the HeBA Consortium. (2025). Preferences regarding disclosure of risk for Parkinson's disease in a population-based study. Movement Disorders Clinical Practice, 12(2), 203-209. https://doi.org/10.1002/mdc3.14264 Markant, D. B. (2026). Asymmetric shape variability biases proportion judgments with icon arrays. Cognitive Science, 50(5), e70227. https://doi.org/10.1111/cogs.70227 Moons, K. G. M., Damen, J. A. A., Kaul, T., Hooft, L., Andaur Navarro, C., Dhiman, P., Beam, A. L., Van Calster, B., Celi, L. A., Denaxas, S., Denniston, A. K., Ghassemi, M., Heinze, G., Kengne, A. P., Maier-Hein, L., Liu, X., Logullo, P., McCradden, M. D., Liu, N., . . . van Smeden, M. (2025). PROBAST+AI: An updated quality, risk of bias, and applicability assessment tool for prediction models using regression or artificial intelligence methods. BMJ, 388, Article e082505. https://doi.org/10.1136/bmj-2024-082505 Postuma, R. B., Berg, D., Stern, M., Poewe, W., Olanow, C. W., Oertel, W., Obeso, J., Marek, K., Litvan, I., Lang, A. E., Halliday, G., Goetz, C. G., Gasser, T., Dubois, B., Chan, P., Bloem, B. R., Adler, C. H., & Deuschl, G. (2015). MDS clinical diagnostic criteria for Parkinson's disease. Movement Disorders, 30(12), 1591–1601. https://doi.org/10.1002/mds.26424 Postuma, R. B., Iranzo, A., Hu, M., Högl, B., Boeve, B. F., Manni, R., Oertel, W. H., Arnulf, I., Ferini-Strambi, L., Puligheddu, M., Antelmi, E., Cochen De Cock, V., Arnaldi, D., Mollenhauer, B., Videnovic, A., Sonka, K., Jung, K.-Y., Kunz, D., Dauvilliers, Y., . . . Pelletier, A. (2019). Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: A multicentre study. Brain, 142(3), 744–759. https://doi.org/10.1093/brain/awz030 Ruiz, J. G., Andrade, A. D., Garcia-Retamero, R., Anam, R., Rodriguez, R., & Sharit, J. (2013). Communicating global cardiovascular risk: Are icon arrays better than numerical estimates in improving understanding, recall and perception of risk? Patient Education and Counseling, 93(3), 394-402. https://doi.org/10.1016/j.pec.2013.06.026 Sanders, G. D., Neumann, P. J., Basu, A., Brock, D. W., Feeny, D., Krahn, M., Kuntz, K. M., Meltzer, D. O., Owens, D. K., Prosser, L. A., Salomon, J. A., Sculpher, M. J., Trikalinos, T. A., Russell, L. B., Siegel, J. E., & Ganiats, T. G. (2016). Recommendations for Conduct, Methodological Practices, and Reporting of Cost-effectiveness Analyses: Second Panel on Cost-Effectiveness in Health and Medicine. JAMA, 316(10), 1093–1103. https://doi.org/10.1001/jama.2016.12195 Schwartz, L. M., Woloshin, S., Black, W. C., & Welch, H. G. (1997). The role of numeracy in understanding the benefit of screening mammography. Annals of Internal Medicine, 127(11), 966-972. https://doi.org/10.7326/0003-4819-127-11-199712010-00003 Van Calster, B., McLernon, D. J., van Smeden, M., Wynants, L., Steyerberg, E. W., & On behalf of Topic Group ‘Evaluating diagnostic tests and prediction models’ of the STRATOS initiative. (2019). Calibration: The Achilles heel of predictive analytics. BMC Medicine, 17(1), Article 230. https://doi.org/10.1186/s12916-019-1466-7 Vickers, A. J., & Elkin, E. B. (2006). Decision curve analysis: A novel method for evaluating prediction models. Medical Decision Making, 26(6), 565–574. https://doi.org/10.1177/0272989x06295361

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