Enantioselective Synthesis of Hexahydroimidazo[1,2- a ]quinolines through Dynamic Kinetic Resolution of Racemic Aziridines
Abstract We report an efficient and practical strategy for the enantioselective synthesis of medicinally relevant hexahydroimidazo[1,2-a]quinolines via a copper(I)-catalyzed domino ring-opening cyclization (DROC) enabled by dynamic kinetic resolution (DKR) of racemic aziridines. The method affords the desired products in good to excellent yields (up to 88%), with outstanding diastereoselectivity (up to >99:1 dr) and high enantioselectivity (up to 94:6 er).
Authors
- Manas K. Ghorai (ORCID: https://orcid.org/0000-0002-0472-4757)
- Poulami Mandal (ORCID: https://orcid.org/0000-0001-8903-7907)
- Diksha Sharma
- Amit K. Sharma
Institutions
- Indian Institute of Technology Kanpur (IN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-09-16
- DOI
- https://doi.org/10.1021/acs.joc.6c01376
- Primary Topic
- Synthesis and Catalytic Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00