Spatially Distinct Bone Marrow Sites Are Asymmetrically Impacted by Inflammatory Cardiovascular Disease
F-FDG bone marrow uptake strongly correlated with inflammatory activity, we applied MarrowMet to map site-specific activation patterns across diverse cardiovascular pathologies, including mouse models of inflammatory atherosclerosis, acute ischemic events, acute respiratory distress syndrome, metabolic syndrome, and aging. MarrowMet guided the selection of bone marrow regions of interest for in-depth mass cytometric analyses, with the skull and sternum emerging as critical sites exhibiting distinct immune and metabolic profiles in cardiovascular disease. These results challenge the prevailing view that femoral marrow represents systemic activity. Together, this work lays a foundation for whole-body exploration of bone marrow heterogeneity, yielding critical insights into cardiovascular disease and associated inflammatory responses, and MarrowMet can be readily adopted to profile other immune mechanisms in a variety of pathologies, including cancer and autoimmune diseases.
Authors
- Jeroen Deckers (ORCID: https://orcid.org/0000-0003-2723-8660)
- Thijs J. Beldman (ORCID: https://orcid.org/0000-0003-4742-636X)
- Jennifer E. Cole (ORCID: https://orcid.org/0000-0002-2247-9628)
- Carlos Pérez‐Medina (ORCID: https://orcid.org/0000-0002-6011-0629)
- Maziar Divangahi (ORCID: https://orcid.org/0000-0002-1254-6110)
- Mandy M. T. van Leent (ORCID: https://orcid.org/0000-0002-9747-1022)
- Krystyna M. Demkiw (ORCID: https://orcid.org/0000-0001-5457-3291)
- Niels P. Riksen (ORCID: https://orcid.org/0000-0001-9197-8124)
- Willem J. M. Mulder (ORCID: https://orcid.org/0000-0001-8665-3878)
- Roy van der Meel (ORCID: https://orcid.org/0000-0002-2200-7946)
- Tom Anbergen (ORCID: https://orcid.org/0000-0002-7155-7709)
- Yuri van Elsas (ORCID: https://orcid.org/0009-0002-2985-3368)
- Esther Lutgens (ORCID: https://orcid.org/0000-0002-2609-5744)
- William Wang (ORCID: https://orcid.org/0009-0008-3844-2281)
- Zahi A. Fayad
- Abraham JP Teunissen
- Iris Versteeg
- Cristina Grao-Roldán (ORCID: https://orcid.org/0009-0000-4174-8531)
- Matthias Nahrendorf
- Claudia Monaco (ORCID: https://orcid.org/0000-0003-1985-4914)
- Filip K. Swirski
- Sheqouia Nauta
- Yohana C. Toner
- Martin Umali
- Leo A.B. Joosten
- Mihai G. Netea
Institutions
- Allen Institute for Brain Science (US)
- Mayo Clinic (US)
- Radboud University Nijmegen (NL)
- Iuliu Hațieganu University of Medicine and Pharmacy (RO)
- McGill University Health Centre (CA)
- Nuffield Orthopaedic Centre (GB)
- Radboud University Medical Center (NL)
- Spanish National Centre for Cardiovascular Research (ES)
- University of Oxford (GB)
- Radboud Institute for Molecular Life Sciences (NL)
- Mayo Clinic in Arizona (US)
- Inflammation Research Foundation (US)
- McGill University (CA)
- Eindhoven University of Technology (NL)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- JACC Basic to Translational Science
- Published
- 2026-09-16
- DOI
- https://doi.org/10.1016/j.jacbts.2026.101660
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00