Sample-to-Answer Serum Diagnostics System-on-Chip

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Institutions

Publication Details

Journal
ACS Sensors
Published
2026-09-16
DOI
https://doi.org/10.1021/acssensors.6c02092
Primary Topic
Microfluidic and Bio-sensing Technologies
Type
article
Field-Weighted Citation Impact
0.00

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article

Sample-to-Answer Serum Diagnostics System-on-Chip

Xiaofeng Liu, Yiwei Liu, Zhiyong Zhang, Zijun Zhao et al.
ACS Sensors
Microfluidic and Bio-sensing Technologies
article

Sample-to-Answer Serum Diagnostics System-on-Chip

Xiaofeng Liu, Yiwei Liu, Zhiyong Zhang, Zijun Zhao, Kemin Wang, Guojun Zhang, Zhengwu Cao, Jiajun Tong, Lu Wan
article en

Abstract

Integrating multiple bioanalytical functions onto a single chip for point-of-care protein detection remains challenging. Here, we introduce a biological detection system-on-chip (BDSoC) that merges the purification capabilities of microfluidic chips with the detection sensitivity of carbon nanotube (CNT) field-effect transistor (FET) biosensors, achieving ultrasensitive analysis of trace protein biomarkers in complex samples. The BDSoC device allows direct and precise detection of tumor biomarkers in undiluted serum across an exceptionally low concentration range from 2 fg/mL to 1 pg/mL and correctly classified all 24 clinical serum samples tested in this study, corresponding to an observed diagnostic accuracy of 100% in this preliminary cohort. The platform is highly scalable, allowing for the future integration of biosensor arrays for multiplexing, advanced fluidic control, and versatile sample processing modules. This work marks a significant advance toward the ultimate vision of the "single-drop blood test" SoC, accelerating the practical deployment of FET biosensors and their evolution in point-of-care diagnostic technologies.

ACS Sensors
King University (US), Central South University (CN), Peking University (CN), Hubei University of Chinese Medicine (CN), Xiangtan University (CN), South University (US)
National Natural Science Foundation of China, Natural Science Foundation of Hunan Province, Hunan Provincial Innovation Foundation for Postgraduate, Scientific Research Foundation of Hunan Provincial Education Department, National Key Research and Development Program of China
Openalex Percentile: Top 21%
Microfluidic and Bio-sensing Technologies
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