Sample-to-Answer Serum Diagnostics System-on-Chip
{"Integrating":[0],"multiple":[1],"bioanalytical":[2],"functions":[3],"onto":[4],"a":[5,17,128],"single":[6],"chip":[7],"for":[8,108,115],"point-of-care":[9,152],"protein":[10,47],"detection":[11,19,32,59],"remains":[12],"challenging.":[13],"Here,":[14],"we":[15],"introduce":[16],"biological":[18],"system-on-chip":[20],"(BDSoC)":[21],"that":[22],"merges":[23],"the":[24,31,109,132,136,142],"purification":[25],"capabilities":[26],"of":[27,34,45,60,96,112,135,145],"microfluidic":[28],"chips":[29],"with":[30],"sensitivity":[33],"carbon":[35],"nanotube":[36],"(CNT)":[37],"field-effect":[38],"transistor":[39],"(FET)":[40],"biosensors,":[41],"achieving":[42],"ultrasensitive":[43],"analysis":[44],"trace":[46],"biomarkers":[48,62],"in":[49,63,87,98,151],"complex":[50],"samples.":[51],"The":[52,102],"BDSoC":[53],"device":[54],"allows":[55],"direct":[56],"and":[57,78,120,148],"precise":[58],"tumor":[61],"undiluted":[64],"serum":[65,84],"across":[66],"an":[67,92],"exceptionally":[68],"low":[69],"concentration":[70],"range":[71],"from":[72],"2":[73],"fg/mL":[74],"to":[75,91],"1":[76],"pg/mL":[77],"correctly":[79],"classified":[80],"all":[81],"24":[82],"clinical":[83],"samples":[85],"tested":[86],"this":[88,99],"study,":[89],"corresponding":[90],"observed":[93],"diagnostic":[94,153],"accuracy":[95],"100%":[97],"preliminary":[100],"cohort.":[101],"platform":[103],"is":[104],"highly":[105],"scalable,":[106],"allowing":[107],"future":[110],"integration":[111],"biosensor":[113],"arrays":[114],"multiplexing,":[116],"advanced":[117],"fluidic":[118],"control,":[119],"versatile":[121],"sample":[122],"processing":[123],"modules.":[124],"This":[125],"work":[126],"marks":[127],"significant":[129],"advance":[130],"toward":[131],"ultimate":[133],"vision":[134],"\\"single-drop":[137],"blood":[138],"test\\"":[139],"SoC,":[140],"accelerating":[141],"practical":[143],"deployment":[144],"FET":[146],"biosensors":[147],"their":[149],"evolution":[150],"technologies.":[154]}
Authors
- Xiaofeng Liu (ORCID: https://orcid.org/0000-0002-0447-5658)
- Yiwei Liu (ORCID: https://orcid.org/0000-0001-7416-4452)
- Zhiyong Zhang (ORCID: https://orcid.org/0000-0003-1622-3447)
- Zijun Zhao
- Kemin Wang
- Guojun Zhang
- Zhengwu Cao
- Jiajun Tong
- Lu Wan
Institutions
- King University (US)
- Central South University (CN)
- Peking University (CN)
- Hubei University of Chinese Medicine (CN)
- Xiangtan University (CN)
- South University (US)
Publication Details
- Journal
- ACS Sensors
- Published
- 2026-09-16
- DOI
- https://doi.org/10.1021/acssensors.6c02092
- Primary Topic
- Microfluidic and Bio-sensing Technologies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province
- Hunan Provincial Innovation Foundation for Postgraduate
- Scientific Research Foundation of Hunan Provincial Education Department
- National Key Research and Development Program of China