Minimal Clinically Important Difference in TETRAS Score for Essential Tremor
{"BACKGROUND:":[0],"Minimum":[1],"clinically":[2,8,15,237],"important":[3],"difference":[4],"(MCID)":[5],"helps":[6],"distinguish":[7],"meaningful":[9,238],"benefit":[10],"from":[11,77,169,192,201],"statistically":[12],"significant,":[13],"but":[14,54],"trivial,":[16],"change.":[17,171],"Modified":[18],"versions":[19],"of":[20,32,84,104,112,255],"the":[21,29,38,68,78,100,108,208,215],"Essential":[22],"Tremor":[23],"Rating":[24],"Assessment":[25],"Scale":[26],"(TETRAS),":[27],"including":[28],"modified":[30],"activities":[31],"daily":[33],"living":[34],"(mADL)":[35],"scale":[36],"and":[37,70,107,127,137,144,183,196,229],"mADL11":[39,71,128,184,199],"scale,":[40],"are":[41,225],"frequently":[42],"used":[43,116,244],"as":[44,117,134],"primary":[45,118],"outcome":[46,246],"measures":[47,58,143,175,247],"in":[48,73,125,181,248],"essential":[49],"tremor":[50],"(ET)":[51],"clinical":[52,257],"trials,":[53],"MCIDs":[55,66,251],"for":[56,67,93,120,131,189,198,227,231,241],"these":[57],"have":[59],"not":[60],"been":[61],"established.":[62],"Here,":[63],"we":[64],"estimated":[65],"mADL":[69,126,182,190,228],"scales":[72],"ET.":[74,249],"METHODS:":[75],"Data":[76],"TRANQUIL":[79],"multicenter,":[80],"randomized":[81],"controlled":[82],"trial":[83],"an":[85],"artificial":[86],"intelligence-driven":[87],"transcutaneous":[88],"peripheral":[89],"nerve":[90],"stimulation":[91],"device":[92],"ET":[94,258],"were":[95,115,129,147,158],"analyzed.":[96],"Anchor-based":[97],"approaches":[98],"using":[99],"Clinical":[101],"Global":[102,110],"Impression":[103,111],"Improvement":[105,113],"(CGI-I)":[106],"Patient":[109],"(PGI-I)":[114],"methods":[119],"MCID":[121,187,219],"estimation.":[122],"Mean":[123],"changes":[124,146,180],"calculated":[130],"participants":[132],"rated":[133],"\\"minimally":[135],"improved\\"":[136],"\\"no":[138],"change.\\"":[139],"Associations":[140],"between":[141],"anchor":[142,174],"score":[145],"assessed":[148],"with":[149,179],"Spearman's":[150],"correlation":[151],"coefficients.":[152],"Receiver":[153],"operating":[154],"characteristic":[155],"(ROC)":[156],"analyses":[157],"performed":[159],"to":[160,194,203],"identify":[161],"cutoff":[162],"values":[163,188,197],"that":[164],"best":[165],"distinguished":[166],"minimal":[167],"improvement":[168],"no":[170],"RESULTS:":[172],"The":[173],"demonstrated":[176],"acceptable":[177],"correlations":[178],"scores.":[185],"Estimated":[186],"ranged":[191,200],"-3.5":[193],"-6.2,":[195],"-1.0":[202],"-4.1":[204,230],"ROC-derived":[205],"estimates":[206,213],"produced":[207],"lowest":[209],"thresholds,":[210],"whereas":[211],"PGI-I-based":[212],"yielded":[214],"highest.":[216],"Our":[217],"recommended":[218],"values,":[220],"based":[221],"on":[222],"patient":[223],"report,":[224],"-6.2":[226],"mADL11.":[232],"CONCLUSIONS:":[233],"This":[234],"study":[235],"establishes":[236],"change":[239],"thresholds":[240],"two":[242],"commonly":[243],"TETRAS-based":[245],"These":[250],"may":[252],"aid":[253],"interpretation":[254],"future":[256],"trials.":[259]}
Authors
- Kelly E. Lyons (ORCID: https://orcid.org/0000-0001-7418-1957)
- Xiaodong Zhu (ORCID: https://orcid.org/0000-0002-6535-4606)
- Rajesh Pahwa (ORCID: https://orcid.org/0000-0003-3176-6466)
- Zhen Zhang (ORCID: https://orcid.org/0000-0002-0804-8741)
- Alberto J. Espay (ORCID: https://orcid.org/0000-0002-3389-136X)
- Sheng‐Han Kuo (ORCID: https://orcid.org/0000-0002-9412-931X)
- Stuart Isaacson (ORCID: https://orcid.org/0000-0002-9914-5706)
- William G. Ondo (ORCID: https://orcid.org/0000-0001-6090-4261)
- Wen Lv
- Hu Yongsheng (ORCID: https://orcid.org/0000-0001-9782-584X)
- Qi Zhao (ORCID: https://orcid.org/0009-0006-1229-1433)
- Zhi Yang
- Holly A. Shill
- Yuan Yuan
Institutions
- PDK International (US)
- Barrow Neurological Institute (US)
- Capital Medical University (CN)
- University of Minnesota System (US)
- Sir Run Run Shaw Hospital (CN)
- Tianjin Medical University General Hospital (CN)
- Methodist Hospital (US)
- Parkinson's Research and Education Foundation (US)
- University of Kansas Medical Center (US)
- First Affiliated Hospital Zhejiang University (CN)
- University of Cincinnati (US)
- Columbia University (US)
Publication Details
- Journal
- Movement Disorders Clinical Practice
- Published
- 2026-09-15
- DOI
- https://doi.org/10.1002/mdc3.70807
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00