A Heat-Promoted Skeletal Rearrangement of 2-Vinyl-2 H -azirines to Pyrroles

Abstract An efficient rearrangement reaction of 2-vinyl 2H-azirines to pyrroles was accomplished under heating conditions. The method is simple and features mild reaction conditions and good functional group tolerance, enabling the efficient synthesis of a series of pyrrole derivatives.

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Publication Details

Journal
The Journal of Organic Chemistry
Published
2026-09-16
DOI
https://doi.org/10.1021/acs.joc.6c00955
Primary Topic
Synthesis and Characterization of Pyrroles
Type
article
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article

A Heat-Promoted Skeletal Rearrangement of 2-Vinyl-2 H -azirines to Pyrroles

Xingang Xie, Zeyuan Wei, Jingyan Wang, Narong Yu et al.
The Journal of Organic Chemistry
Synthesis and Characterization of Pyrroles
article

A Heat-Promoted Skeletal Rearrangement of 2-Vinyl-2 H -azirines to Pyrroles

Xingang Xie, Zeyuan Wei, Jingyan Wang, Narong Yu, Xing Huo
article en

Abstract

Abstract An efficient rearrangement reaction of 2-vinyl 2H-azirines to pyrroles was accomplished under heating conditions. The method is simple and features mild reaction conditions and good functional group tolerance, enabling the efficient synthesis of a series of pyrrole derivatives.

The Journal of Organic Chemistry
Lanzhou University of Technology (CN), Lanzhou University (CN)
Affordable and clean energy
Openalex Percentile: Top 20%
Synthesis and Characterization of Pyrroles
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