α-Tocopherol rescues lipid-induced impairment of autophagy via mTOR/ULK1 signaling in macrophages
findings suggest that α-TOC reduces lipid accumulation and inhibits foam cell formation in macrophages by enhancing autophagic activity in association with reduced mTOR phosphorylation and increased ULK1 Ser555 phosphorylation. This study provides mechanistic insights into the potential anti-atherosclerotic effects of α-TOC at the cellular level, offering a theoretical basis for its further investigation as a therapeutic candidate for atherosclerosis.
Authors
- S Wu (ORCID: https://orcid.org/0000-0001-8587-3334)
- Limei Wu (ORCID: https://orcid.org/0000-0002-4979-7343)
- Jiaxing Zhao (ORCID: https://orcid.org/0000-0003-4548-2026)
- Xuehui Liu (ORCID: https://orcid.org/0000-0003-2842-7404)
- Zenghui Liu (ORCID: https://orcid.org/0000-0001-7773-9995)
- Qijun Chen (ORCID: https://orcid.org/0000-0003-0356-7435)
- Huayu Yin
- Lu Kuang
- Dabin Liu
Institutions
- Mudanjiang Medical University (CN)
- Twelfth Guangzhou City People's Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Korean Journal of Physiology and Pharmacology
- Published
- 2026-09-16
- DOI
- https://doi.org/10.4196/kjpp.25.375
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangzhou Municipal Science and Technology Project
- Basic and Applied Basic Research Foundation of Guangdong Province