Mechanical load as an endogenous tumor suppressor: Nesprin-2-mediated mechanotransduction reshapes the cancer epigenome

In a recent study published in Science , Ciucci et al. show that physiological mechanical loading suppresses cancer cell proliferation in the heart through Nesprin-2-dependent nuclear mechanotransduction and epigenetic remodeling. 1 These findings identify cardiac mechanics as an endogenous barrier to cancer and suggest new mechanically and epigenetically informed therapeutic strategies.