Acridinone-sulfonamide hybrids: synthesis, photophysical properties, DFT Analysis, insilico ADMET and antiviral docking against adenovirus

A series of acridinone-based sulfonamides was synthesized and characterized using spectroscopic techniques. Computational studies revealed the influence of substituent effects on the electronic properties and stability of the synthesized derivatives, while molecular electrostatic potential analysis identified the most reactive interaction sites. Molecular docking and ADMET assessments highlighted several derivatives with favourable predicted binding and pharmacokinetic characteristics. In addition, these compounds exhibited noteworthy photophysical properties, exhibiting enhanced fluorescence performance. These findings demonstrate the multifunctional potential of acridinone-sulfonamide hybrids and support their further biological investigation.