FORMULATION AND EVALUATION OF HIGH DENSITY MATRIX TABLET OF GLIPIZIDE : A REVIEW

ABSTRACTThe objective of the present research work was to formulate and evaluate high-density matrix tablets of Glipizide, asecondgeneration sulfonylurea, to achieve sustained gastroretentive drug delivery for prolonged glycemic control in Type 2diabetes mellitus. Glipizide matrix tablets were prepared by the direct compression method utilizing HydroxypropylMethylcellulose (HPMC) as the rate-controlling polymer, combined with Titanium Dioxide and Zinc Oxide serving as highdensity modifiers and enhancers. Pre-formulation testing indicated satisfactory flow properties, showing an angle of repose of27.5°, a Carr’s compressibility index of 14.81%, and a Hausner ratio of 1.17. Fourier Transform Infrared Spectroscopy (FTIR)and Differential Scanning Calorimetry (DSC) investigations confirmed physical and structural compatibility between the activedrug compound and the chosen matrix excipients. The formulated tablets demonstrated uniform post-compression attributesacross all test batches. The average tablet weight aligned tightly with the 400 mg target specification, tablet thickness measuredwithin 5.0 ± 0.5 mm, hardness ranged between 3.5 to 7.1 Kp, and friability loss values remained well under the 1.0% officialthreshold limit. Drug content uniformity evaluations showed high and uniform values (≥99.1%). In vitro dissolution profilesestablished that the HPMC-based high-density system effectively sustained the release of the practically water-insolubleGlipizide molecule for over 12 hours. Accelerated stability evaluations performed according to ICH protocols at 40 ± 2°C and75 ± 5% RH revealed no significant deviations in physical integrity, mechanical hardness, or absolute drug entrapment over a4-week period. This investigation successfully proves that high-density matrix systems offer a mechanically robust andscalable technique for improving the therapeutic baseline of short-acting antidiabetic agents.