EBNA1 381-452 and Cross-Reactive Antibody Responses Reveal Immune Signatures in Multiple Sclerosis

BACKGROUND AND OBJECTIVES: response in peripheral blood and CSF of a clinically well-defined cohort of patients with MS and identify whether cross-reactive antibody responses are linked to disease characteristics. METHODS: region and their corresponding autoantigens using indirect ELISA in plasma of patients with untreated relapse-onset MS (n = 211) and healthy spouse controls (n = 63). We extended this analysis to paired serum-CSF samples from 61 patients with MS to determine intrathecal IgG responses. RESULTS: -high cross-reactive immune signature suggested intrathecal synthesis. DISCUSSION: -directed immune responses among patients with MS, differing in cross-reactivity and intrathecal enrichment.