Rethinking the concept of disease modification in an evolving Parkinson's disease treatment landscape

We are in an era in which increasing numbers of potentially disease-modifying treatments for Parkinson's disease are being tested in clinical development. Current definitions of disease modification have inherent limitations; hence there is a need to establish a clear, unified definition. This unified definition of disease modification should be applicable to both idiopathic and genetic forms of Parkinson's disease. In addition to motor function, it must address important milestones (e.g., cognition, autonomic dysfunction) across all disease stages. This review examines existing definitions and highlights the need for a more holistic approach that integrates the perspectives of patients, healthcare professionals, and researchers.

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Publication Details

Journal
Journal of Parkinson s Disease
Published
2026-09-15
DOI
https://doi.org/10.1177/1877718x261481704
Primary Topic
Parkinson's Disease Mechanisms and Treatments
Type
article
Field-Weighted Citation Impact
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article

Rethinking the concept of disease modification in an evolving Parkinson's disease treatment landscape

Angelo Antonini, Maria De Leon, Günter U. Höglinger, David J. Pedrosa et al.
Journal of Parkinson s Disease
Parkinson's Disease Mechanisms and Treatments
article

Rethinking the concept of disease modification in an evolving Parkinson's disease treatment landscape

Angelo Antonini, Maria De Leon, Günter U. Höglinger, David J. Pedrosa, Claire Henchcliffe, Kevin Kwok, Tom Foltynie, Robert E Gross, Jens Volkmann, Jean-Christophe Corvol, Thomas Gasser
article en

Abstract

We are in an era in which increasing numbers of potentially disease-modifying treatments for Parkinson's disease are being tested in clinical development. Current definitions of disease modification have inherent limitations; hence there is a need to establish a clear, unified definition. This unified definition of disease modification should be applicable to both idiopathic and genetic forms of Parkinson's disease. In addition to motor function, it must address important milestones (e.g., cognition, autonomic dysfunction) across all disease stages. This review examines existing definitions and highlights the need for a more holistic approach that integrates the perspectives of patients, healthcare professionals, and researchers.

Journal of Parkinson s Disease
University of Padua (IT), Philipps University of Marburg (DE), University of California, Irvine (US), University of Würzburg (DE), German Center for Neurodegenerative Diseases (DE), Davis Phinney Foundation (US), LMU Klinikum (DE), Sorbonne Université (FR), Assistance Publique – Hôpitaux de Paris (FR), Munich Cluster for Systems Neurology (DE), Institut de Myologie (FR), Pitié-Salpêtrière Hospital (FR), University Children's Hospital Tübingen (DE), IRCCS San Camillo Hospital (IT), Expert System (Italy) (IT), Laboratoire Médiations (FR), Ludwig-Maximilians-Universität München (DE)
Good health and well-being
Openalex Percentile: Top 11%
Parkinson's Disease Mechanisms and Treatments
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