Lower Urinary Tract Dysfunction in Renal Transplant Candidates: A Scoping Review of Assessment Methods and Post‐Transplant Urological Outcomes

ABSTRACT Purpose We performed a scoping review to map the available evidence regarding pre‐transplant lower urinary tract dysfunction (LUTD) assessment in adult renal transplant candidates and to summarise reported associations between pre‐transplant LUTD and post‐transplant urological outcomes. Methods Electronic databases were searched up to 30th September 2025. Studies were included if they assessed lower urinary tract function prior to kidney transplantation using clinical history, questionnaires or investigations and reported post‐transplant urological complications and/or graft outcomes. Risk of bias was assessed using ROBINS‐I V2 for comparative studies and QUIPS for prognostic studies. Owing to substantial clinical and methodological heterogeneity, findings were synthesised narratively. Results A total of 11 studies comprising 4471 patients met the inclusion criteria. Assessment strategies varied considerably across studies, ranging from clinical history alone to validated symptom questionnaires, uroflowmetry and urodynamic testing. Six studies reported urinary tract infection (UTI) outcomes, with most suggesting an increased risk in patients with pre‐transplant LUTD. Evidence for acute urinary retention and urosepsis was limited but directionally consistent with higher complication rates. Data on graft survival outcomes were sparse and heterogeneous, with some studies suggesting an association between pre‐transplant LUTD and poorer graft survival. Conclusions Pre‐transplant LUTD appears to be associated with an increased risk of post‐transplant urological complications, particularly UTIs. However, the evidence is heterogeneous and largely observational, predominantly derived from retrospective studies, with limited data on graft outcomes. This scoping review highlights marked heterogeneity in pre‐transplant LUTD assessment and supports the development of a standardised assessment framework to guide future research and clinical practice.

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Journal
Neurourology and Urodynamics
Published
2026-09-16
DOI
https://doi.org/10.1002/nau.70442
Primary Topic
Urinary Tract Infections Management
Type
article
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article

Lower Urinary Tract Dysfunction in Renal Transplant Candidates: A Scoping Review of Assessment Methods and Post‐Transplant Urological Outcomes

Mehwash Nadeem, Imran Ahmad, Emma Aitken, David B. Kingsmore et al.
Neurourology and Urodynamics
Urinary Tract Infections Management
article

Lower Urinary Tract Dysfunction in Renal Transplant Candidates: A Scoping Review of Assessment Methods and Post‐Transplant Urological Outcomes

Mehwash Nadeem, Imran Ahmad, Emma Aitken, David B. Kingsmore, Dhruv S. Sahni
article en

Abstract

ABSTRACT Purpose We performed a scoping review to map the available evidence regarding pre‐transplant lower urinary tract dysfunction (LUTD) assessment in adult renal transplant candidates and to summarise reported associations between pre‐transplant LUTD and post‐transplant urological outcomes. Methods Electronic databases were searched up to 30th September 2025. Studies were included if they assessed lower urinary tract function prior to kidney transplantation using clinical history, questionnaires or investigations and reported post‐transplant urological complications and/or graft outcomes. Risk of bias was assessed using ROBINS‐I V2 for comparative studies and QUIPS for prognostic studies. Owing to substantial clinical and methodological heterogeneity, findings were synthesised narratively. Results A total of 11 studies comprising 4471 patients met the inclusion criteria. Assessment strategies varied considerably across studies, ranging from clinical history alone to validated symptom questionnaires, uroflowmetry and urodynamic testing. Six studies reported urinary tract infection (UTI) outcomes, with most suggesting an increased risk in patients with pre‐transplant LUTD. Evidence for acute urinary retention and urosepsis was limited but directionally consistent with higher complication rates. Data on graft survival outcomes were sparse and heterogeneous, with some studies suggesting an association between pre‐transplant LUTD and poorer graft survival. Conclusions Pre‐transplant LUTD appears to be associated with an increased risk of post‐transplant urological complications, particularly UTIs. However, the evidence is heterogeneous and largely observational, predominantly derived from retrospective studies, with limited data on graft outcomes. This scoping review highlights marked heterogeneity in pre‐transplant LUTD assessment and supports the development of a standardised assessment framework to guide future research and clinical practice.

Neurourology and Urodynamics
Cancer Research UK (GB), South Tees Hospitals NHS Foundation Trust (GB), Queen Elizabeth University Hospital (GB), University of Glasgow (GB)
Reduced inequalities
Openalex Percentile: Top 11%
Urinary Tract Infections Management
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