Prospective Systematic Screening for Transthyretin Amyloid Cardiomyopathy in Cardiology Inpatients With Left Ventricular Hypertrophy: the IMPACT Study
{"BACKGROUND:":[0],"Transthyretin":[1],"cardiac":[2,107],"amyloidosis":[3],"(ATTR-CM)":[4],"is":[5],"an":[6],"underdiagnosed":[7],"severe":[8],"cardiomyopathy":[9],"in":[10,26,70,139,239],"older":[11],"adults.":[12],"Current":[13],"diagnostic":[14,128,237],"strategies":[15],"rely":[16],"on":[17,23],"clinical":[18],"\\"red":[19],"flags\\",":[20],"but":[21],"data":[22],"systematic":[24,225],"screening":[25,226],"minimally":[27,219],"selected":[28,220],"populations":[29],"remain":[30],"limited.":[31],"We":[32],"aimed":[33],"to":[34,49,91],"describe":[35],"the":[36,190],"prevalence":[37,230],"of":[38,80,141,181,201,231,248],"ATTR-CM":[39,103,136,194,211],"among":[40],"cardiology":[41,71,221],"inpatients":[42],"with":[43,53,72,83,150,223],"left":[44],"ventricular":[45],"hypertrophy":[46],"(LVH)":[47],"and":[48,100,122,133,179,212,242,246],"identify":[50],"parameters":[51],"associated":[52,149],"its":[54],"diagnosis.":[55],"METHODS":[56],"AND":[57],"RESULTS:":[58],"This":[59],"prospective":[60],"single-center":[61],"study":[62],"included":[63],"consecutive":[64],"patients":[65,96,143,214],"aged":[66],"≥60":[67],"years":[68],"hospitalized":[69],"echocardiographic":[73],"LVH":[74],"(wall":[75],"thickness":[76],"≥12":[77],"mm),":[78],"irrespective":[79],"etiology.":[81],"Patients":[82],"known":[84],"amyloidosis,":[85],"prior":[86],"heart":[87],"transplantation,":[88],"or":[89],"contraindication":[90],"scintigraphy":[92],"were":[93,147],"excluded.":[94],"All":[95],"underwent":[97],"immunologic":[98],"testing":[99,238],"technetium-99m":[101],"scintigraphy.":[102],"was":[104,137],"diagnosed":[105,138],"by":[106],"uptake":[108],"(Perugini":[109],"grade":[110],"≥2)":[111],"without":[112],"significant":[113],"monoclonal":[114],"gammopathy.":[115],"Multivariable":[116],"logistic":[117],"regression":[118],"identified":[119,227],"independent":[120],"associations":[121],"receiver-operating":[123],"characteristic":[124],"curve":[125],"analysis":[126],"assessed":[127],"performance.":[129],"Between":[130],"October":[131],"2021":[132],"June":[134],"2023,":[135],"29":[140],"400":[142],"(7.3%).":[144],"Four":[145],"variables":[146],"independently":[148],"ATTR-CM:":[151],"basal":[152],"longitudinal":[153],"strain":[154],"(BLS)":[155],"(odds":[156],"ratio":[157],"[OR]":[158],"0.84,":[159],"95%":[160,167,176,185],"CI":[161,168,177,186],"0.74-0.95),":[162],"non-sinus":[163],"rhythm":[164],"(OR":[165,174,183],"3.85,":[166],"1.30-11.11),":[169],"bilateral":[170],"carpal":[171],"tunnel":[172],"syndrome":[173],"3.48,":[175],"1.09-11.14),":[178],"history":[180],"stroke":[182],"8.67,":[184],"2.65-28.34).":[187],"BLS":[188,233],"showed":[189],"highest":[191],"discrimination":[192],"for":[193],"(AUC":[195],"0.81).":[196],"During":[197],"a":[198,218,228],"median":[199],"follow-up":[200],"3.31":[202],"years,":[203],"all-cause":[204],"mortality":[205],"did":[206],"not":[207],"significantly":[208],"differ":[209],"between":[210],"non-ATTR-CM":[213],"(p=0.137).":[215],"CONCLUSION:":[216],"In":[217],"population":[222],"LVH,":[224],"substantial":[229],"ATTR-CM.":[232,249],"may":[234],"help":[235],"prioritize":[236],"routine":[240],"practice":[241],"facilitate":[243],"earlier":[244],"identification":[245],"management":[247]}
Authors
- Pierre‐Jean Saulnier (ORCID: https://orcid.org/0000-0003-1862-4252)
- Claire Bouleti (ORCID: https://orcid.org/0000-0001-6922-0093)
- Benjamin Alos (ORCID: https://orcid.org/0000-0002-6434-2873)
- Maxime Doublet (ORCID: https://orcid.org/0009-0005-3301-2862)
- Céline Boucher
- Matthieu Proust
- Elsa Beard
- T. Rosenberg
- Lisa Durocher (ORCID: https://orcid.org/0009-0009-5942-9964)
- Michèle Grosdenier
- Luc-Philippe Christiaens
- Stéphanie Ragot
- Benjamin Khalifa
Institutions
- Inserm (FR)
- Université de Poitiers (FR)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre Hospitalier Universitaire de Poitiers (FR)
- Laboratoire Vision Action Cognition (FR)
- Fondation pour l’innovation en Cadiométabolisme et Nutrition (FR)
- Alliance nationale pour les sciences de la vie et de la santé (FR)
Publication Details
- Journal
- European Heart Journal - Cardiovascular Imaging
- Published
- 2026-09-14
- DOI
- https://doi.org/10.1093/ehjci/jeag254
- Primary Topic
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00