Improving the Hydrophilicity of the Drugs Paclitaxel, Violacein, and Tetrandrine Using Carbon-Based Quantum Dots

Carbon-based quantum dots and their nitrogen- and sulfur-doped derivatives were used as platforms to improve the aqueous solubility for Paclitaxel, Violacein and Tetrandrine, drugs with known high partition coefficients (Log P). Paclitaxel, Violacein and Tetrandrine showed a significant reduction in their partition coefficient values by coupling with the carbon-based quantum dots. Paclitaxel’s partition coefficient value decreased from 3.96 to 0.2, Violacein’s from 3.34 to 1.17, and Tetrandrine’s from 2.5 to 1.57, thus demonstrating a significant reduction in their hydrophobicity without being encapsulated. The efficiency of each type of carbon-based quantum dot in lowering each drug’s Log P varied and this behavior was correlated with the nature of the surface interaction between each drug and each of the carbon-based quantum dots.

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Journal
Nanomaterials
Published
2026-09-16
DOI
https://doi.org/10.3390/nano16181166
Primary Topic
Berberine and alkaloids research
Type
article
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article

Improving the Hydrophilicity of the Drugs Paclitaxel, Violacein, and Tetrandrine Using Carbon-Based Quantum Dots

Marvin J. Bayro, Brad R. Weiner, Rafael Maldonado‐Hernández, Valerie Ortiz-Gómez et al.
Nanomaterials
Berberine and alkaloids research
article

Improving the Hydrophilicity of the Drugs Paclitaxel, Violacein, and Tetrandrine Using Carbon-Based Quantum Dots

Marvin J. Bayro, Brad R. Weiner, Rafael Maldonado‐Hernández, Valerie Ortiz-Gómez, Gerardo Morell, Nataniel Medina-Berríos, Solimar Collazo-Hernandez, Alexis Lavín Flores, Rafael A. Villanueva-Nogueras, Alondra Veloz-Bonilla, MiaSara Perez-Salvá, Luis Prieto-Costas, Christine Wu, Katherine Ayala, Fabiola M. Rosa-Suárez, Keyla A. López-Pérez
article en

Abstract

Carbon-based quantum dots and their nitrogen- and sulfur-doped derivatives were used as platforms to improve the aqueous solubility for Paclitaxel, Violacein and Tetrandrine, drugs with known high partition coefficients (Log P). Paclitaxel, Violacein and Tetrandrine showed a significant reduction in their partition coefficient values by coupling with the carbon-based quantum dots. Paclitaxel’s partition coefficient value decreased from 3.96 to 0.2, Violacein’s from 3.34 to 1.17, and Tetrandrine’s from 2.5 to 1.57, thus demonstrating a significant reduction in their hydrophobicity without being encapsulated. The efficiency of each type of carbon-based quantum dot in lowering each drug’s Log P varied and this behavior was correlated with the nature of the surface interaction between each drug and each of the carbon-based quantum dots.

NanomaterialsVol. 16(18)
University of Puerto Rico at Cayey (PR), University of Puerto Rico at Río Piedras (PR), University of Puerto Rico System (PR), Smith College (US), National Coalition of Independent Scholars, University of Turabo (PR), Berea College (US)
Openalex Percentile: Top 13%
Berberine and alkaloids research
DOIOpen Access PDFOpenAlex
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