O‐ GlcNAcylation : A Metabolic‐Immune Hub Regulating Macrophage Fate and Osteoclast Differentiation

{"BACKGROUND:":[0],"O-GlcNAcylation":[1,110],"is":[2,111],"a":[3,23,32,102,114,156],"dynamic":[4],"and":[5,14,26,42,68,82,96,140,149],"reversible":[6],"post-translational":[7],"modification":[8],"of":[9,35,71,105,133],"serine/threonine":[10],"residues":[11],"on":[12,59],"cytoplasmic":[13],"nuclear":[15],"proteins.":[16],"Although":[17],"it":[18],"has":[19,49],"been":[20,51],"implicated":[21],"as":[22,91,113],"\\"differentiation":[24],"switch":[25],"functional":[27],"regulator\\"":[28],"in":[29,62,163],"osteoclast":[30,73,147],"biology,":[31],"systematic":[33],"synthesis":[34],"its":[36,43],"role":[37],"across":[38],"the":[39,69,72,106,127,142],"macrophage-osteoclast":[40,128],"axis":[41],"contribution":[44],"to":[45,100],"bone":[46,94,98,119,161],"remodeling":[47,120],"disorders":[48],"not":[50],"elucidated.":[52],"METHODS:":[53],"The":[54,76],"present":[55],"study":[56],"examines":[57],"evidence":[58,87],"O-GlcNAc":[60,152],"cycling":[61],"macrophage":[63],"polarization,":[64],"RANKL":[65],"signaling":[66,138],"amplification,":[67],"maintenance":[70],"transcriptional":[74,143],"program.":[75],"analysis":[77],"integrates":[78],"findings":[79],"from":[80,88],"cellular":[81],"molecular":[83],"studies":[84],"with":[85],"clinical":[86],"diseases":[89],"such":[90],"osteoporosis,":[92],"inflammatory":[93],"destruction,":[95],"tumor":[97],"metastasis":[99],"provide":[101,155],"comprehensive":[103],"overview":[104],"underlying":[107],"mechanisms.":[108],"RESULTS:":[109],"emerging":[112],"pivotal":[115],"regulator":[116],"that":[117,145],"disrupts":[118],"equilibrium":[121],"through":[122],"multiple":[123],"interconnected":[124],"mechanisms":[125],"along":[126],"axis.":[129],"It":[130],"promotes":[131],"polarization":[132],"pro-inflammatory":[134],"macrophages,":[135],"amplifies":[136],"RANKL-mediated":[137],"cascades,":[139],"stabilizes":[141],"programs":[144],"drive":[146],"differentiation":[148],"function.":[150],"CONCLUSION:":[151],"glycosylation":[153],"may":[154],"novel":[157],"approach":[158],"for":[159],"restoring":[160],"homeostasis":[162],"skeletal":[164],"diseases.":[165]}

Authors

Institutions

Publication Details

Journal
Oral Diseases
Published
2026-09-15
DOI
https://doi.org/10.1111/odi.70498
Primary Topic
Bone Metabolism and Diseases
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
article

O‐ GlcNAcylation : A Metabolic‐Immune Hub Regulating Macrophage Fate and Osteoclast Differentiation

Yanling Zhang, Kun Tian, Nan Zhuang, Xin‐kui Zhang et al.
Oral Diseases
Bone Metabolism and Diseases
article

O‐ GlcNAcylation : A Metabolic‐Immune Hub Regulating Macrophage Fate and Osteoclast Differentiation

Yanling Zhang, Kun Tian, Nan Zhuang, Xin‐kui Zhang, Jing Zhang
article en

Abstract

BACKGROUND: O-GlcNAcylation is a dynamic and reversible post-translational modification of serine/threonine residues on cytoplasmic and nuclear proteins. Although it has been implicated as a "differentiation switch and functional regulator" in osteoclast biology, a systematic synthesis of its role across the macrophage-osteoclast axis and its contribution to bone remodeling disorders has not been elucidated. METHODS: The present study examines evidence on O-GlcNAc cycling in macrophage polarization, RANKL signaling amplification, and the maintenance of the osteoclast transcriptional program. The analysis integrates findings from cellular and molecular studies with clinical evidence from diseases such as osteoporosis, inflammatory bone destruction, and tumor bone metastasis to provide a comprehensive overview of the underlying mechanisms. RESULTS: O-GlcNAcylation is emerging as a pivotal regulator that disrupts bone remodeling equilibrium through multiple interconnected mechanisms along the macrophage-osteoclast axis. It promotes polarization of pro-inflammatory macrophages, amplifies RANKL-mediated signaling cascades, and stabilizes the transcriptional programs that drive osteoclast differentiation and function. CONCLUSION: O-GlcNAc glycosylation may provide a novel approach for restoring bone homeostasis in skeletal diseases.

Oral Diseases
Shanxi Medical University (CN), Weifang People's Hospital (CN), Central Hospital of Zibo (CN), Weifang Chinese Medicine Hospital (CN), Weifang University (CN)
Openalex Percentile: Top 18%
Bone Metabolism and Diseases
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.