Viral hijacking of the host ubiquitin-proteasome system for immune escape
E3 ubiquitin ligases regulate protein turnover and signaling by mediating degradative or nondegradative types of ubiquitylation. In the 20 August 2026 issue of Science , Glassman et al. identified mechanisms by which viral proteins commandeer the ubiquitin-proteasome system to dysregulate innate immunity, unveiling potential avenues for designing antiviral interventions.
Authors
- Michaela U. Gack (ORCID: https://orcid.org/0000-0002-2163-2598)
- Junji Zhu (ORCID: https://orcid.org/0000-0003-2968-180X)
Institutions
- Cleveland Clinic Florida (US)
Publication Details
- Journal
- Science Signaling
- Published
- 2026-09-15
- DOI
- https://doi.org/10.1126/scisignal.aek8777
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00