High Adhesion Superoleophobic Oil Microdroplets to Create Ocular Hypertension In Vivo

{"Ocular":[0],"hypertension":[1,43],"is":[2,33],"commonly":[3],"linked":[4],"with":[5,83,89],"glaucomatous":[6],"neurodegeneration.":[7],"To":[8],"investigate":[9],"the":[10,28,94,127],"mechanisms":[11],"of":[12,66],"glaucoma,":[13],"in":[14,27,36,73,123,132],"vivo":[15,37],"models":[16],"typically":[17],"induce":[18],"intraocular":[19],"pressure":[20],"elevation":[21,61],"by":[22,109],"obstructing":[23],"aqueous":[24],"humor":[25],"flow":[26],"trabecular":[29,102],"meshwork.":[30],"However,":[31],"there":[32],"no":[34],"satisfying":[35],"model":[38,56,140],"to":[39],"maintain":[40],"stable":[41],"ocular":[42],"and":[44,62,98,148],"replicate":[45],"neurodegenerative":[46],"features":[47],"accurately.":[48],"Here,":[49],"we":[50,119],"introduce":[51],"an":[52,79,121],"injectable":[53,137],"oil":[54,76,95,115,138],"microdroplet":[55,139],"that":[57],"achieves":[58],"sustained":[59],"IOP":[60],"a":[63,105,142],"44.3%":[64],"loss":[65],"retinal":[67],"ganglion":[68],"cells":[69],"within":[70,100],"four":[71],"weeks":[72],"mice.":[74],"The":[75],"microdroplets":[77,96],"exhibit":[78],"underwater":[80],"\\"superoleophobic\\"":[81],"state":[82],"high":[84],"adhesion":[85],"forces":[86],"upon":[87],"contact":[88],"tissue.":[90],"Upon":[91],"intracameral":[92],"injection,":[93],"deform":[97],"retain":[99],"various-sized":[101],"architectures":[103],"via":[104],"\\"self-locking\\"":[106],"mechanism":[107],"driven":[108],"differential":[110],"Laplace":[111],"pressures.":[112],"Applying":[113],"this":[114],"microdroplet-induced":[116],"mouse":[117],"model,":[118],"observed":[120,131],"increase":[122],"nocturnal":[124],"sleepiness,":[125],"reflecting":[126],"increased":[128],"daytime":[129],"sleepiness":[130],"human":[133],"glaucoma":[134,146],"patients.":[135],"This":[136],"provides":[141],"platform":[143],"for":[144],"studying":[145],"progression":[147],"evaluating":[149],"potential":[150],"therapeutic":[151],"interventions.":[152]}

Authors

Institutions

Publication Details

Journal
Small
Published
2026-09-14
DOI
https://doi.org/10.1002/smll.202600069
Primary Topic
Retinal and Macular Surgery
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
article

High Adhesion Superoleophobic Oil Microdroplets to Create Ocular Hypertension In Vivo

Eunji Hong, Siyuan Rao, Qianbin Wang, Ruobai Xiao et al.
Small
Retinal and Macular Surgery
article

High Adhesion Superoleophobic Oil Microdroplets to Create Ocular Hypertension In Vivo

Eunji Hong, Siyuan Rao, Qianbin Wang, Ruobai Xiao, Lin Chen, Sizhe Huang, Dorcas Matuwana, Geunho Jang, Mengwen Xiong, Nicolle Gudiel Winter
article en

Abstract

Ocular hypertension is commonly linked with glaucomatous neurodegeneration. To investigate the mechanisms of glaucoma, in vivo models typically induce intraocular pressure elevation by obstructing aqueous humor flow in the trabecular meshwork. However, there is no satisfying in vivo model to maintain stable ocular hypertension and replicate neurodegenerative features accurately. Here, we introduce an injectable oil microdroplet model that achieves sustained IOP elevation and a 44.3% loss of retinal ganglion cells within four weeks in mice. The oil microdroplets exhibit an underwater "superoleophobic" state with high adhesion forces upon contact with tissue. Upon intracameral injection, the oil microdroplets deform and retain within various-sized trabecular architectures via a "self-locking" mechanism driven by differential Laplace pressures. Applying this oil microdroplet-induced mouse model, we observed an increase in nocturnal sleepiness, reflecting the increased daytime sleepiness observed in human glaucoma patients. This injectable oil microdroplet model provides a platform for studying glaucoma progression and evaluating potential therapeutic interventions.

Small
Binghamton University (US), University of Massachusetts Amherst (US)
Life below water
Openalex Percentile: Top 11%
Retinal and Macular Surgery
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.