Efficacy of a Terminalia chebula - Boswellia serrata Combination in Lipopolysaccharide-Induced Neuroinflammation in Sprague Dawley Rats

OBJECTIVE: models. METHODS: , Sprague Dawley rats were challenged with LPS and treated with LN19184. Behavioral assessments of spatial learning, working memory, and recognition memory were conducted. Hippocampal oxidative stress, inflammatory markers, apoptosis-related proteins, and neurodegenerative or synaptic plasticity-associated proteins were analyzed. RESULTS: < 0.05), suggesting enhanced neuroprotection and synaptic plasticity. CONCLUSION: LN19184 mitigated LPS-induced neuroinflammation, oxidative stress, apoptosis-related signaling, and neuronal dysfunction markers, while improving cognitive performance in rats. These findings suggest that LN19184 exerts neuroprotective effects and warrants further investigation for its potential to mitigate inflammation-associated neuronal dysfunction.