An immune related cell death index for prognostic stratification and immunotherapy response prediction in oral cancer

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Publication Details

Journal
Translational Oncology
Published
2026-09-14
DOI
https://doi.org/10.1016/j.tranon.2026.102987
Primary Topic
Ferroptosis and cancer prognosis
Type
article
Field-Weighted Citation Impact
0.00
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article

An immune related cell death index for prognostic stratification and immunotherapy response prediction in oral cancer

Zhaochen Hu, Yingying Zong, Guihong Liu, Peijun Qi et al.
Translational Oncology
Ferroptosis and cancer prognosis
article

An immune related cell death index for prognostic stratification and immunotherapy response prediction in oral cancer

Zhaochen Hu, Yingying Zong, Guihong Liu, Peijun Qi, Liangsicheng Tang, Zhao Liu, Jinglin, Jing Ding, Hang Yu, Jiao Lu
article en

Abstract

Immune-related cell death (IRCD) plays a crucial role in the immune microenvironment, development, and deterioration of oral cancer. However, reliable immune-related cell death profiles have not been explored. In this study, based on multiple oral cancer datasets such as TCGA, tumors were divided into two immune subtypes, "Hot" and "Cold", using the ConsensusClusterPlus algorithm, and significant differences were found between the two in immune cell infiltration, microenvironment activity, and immunotherapy responsiveness. The immune-related cell death index (IRCDI) based on immune-related cell death gene (IRCDG) was further constructed to reveal that IRCDI can be used as an independent prognostic indicator and is closely related to immune activity, gene mutation characteristics and a variety of signaling pathways. Both single cell analysis and immunosubtype analysis showed that low IRCDI was closely related to enhanced immunocompetence. Although IRCDI has a limited predictive role in the TIDE algorithm, it has a good predictive ability in multiple real immunotherapy cohorts and shows specific sensitivity to different drugs, suggesting that IRCDI is expected to be an important biomarker to guide individualized treatment of oral cancer.

Translational OncologyVol. 73
Xuzhou Medical College (CN), Affiliated Hospital of Xuzhou Medical College (CN)
Good health and well-being
Openalex Percentile: Top 13%
Ferroptosis and cancer prognosis
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