Metabolic matching shapes organ-specific metastasis

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Publication Details

Journal
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Published
2026-09-14
DOI
https://doi.org/10.1016/j.bbcan.2026.189705
Primary Topic
Cancer, Hypoxia, and Metabolism
Type
article
Field-Weighted Citation Impact
0.00
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article

Metabolic matching shapes organ-specific metastasis

Patricia Altea-Manzano, Cristina Álvarez-Álvarez
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Cancer, Hypoxia, and Metabolism
article

Metabolic matching shapes organ-specific metastasis

Patricia Altea-Manzano, Cristina Álvarez-Álvarez
article en

Abstract

Metastasis is the leading cause of cancer-related mortality, yet the mechanisms driving organ-specific colonization remain incompletely understood. Increasing evidence suggests that metastatic success depends on a "metabolic match" between disseminated tumor cells and the microenvironment of the target organ. In this mini-review, we discuss how intrinsic metabolic programs inherited from the primary tumor interact with extrinsic factors such as nutrient availability, redox balance, extracellular matrix remodeling, and organ-resident cells to shape metastatic organotropism. We propose that the interplay between cancer cell metabolic plasticity and tissue-specific metabolic landscapes critically determines metastatic fitness and may uncover new therapeutic vulnerabilities.

Biochimica et Biophysica Acta (BBA) - Reviews on CancerVol. 1881(6)
Centro Andaluz de Biología Molecular y Medicina Regenerativa (ES)
Good health and well-being
Openalex Percentile: Top 15%
Cancer, Hypoxia, and Metabolism
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