HBr-Catalyzed Construction of Sulfur-Containing Heterocycles via Difunctionalization of Alkenes
Abstract Sulfur-containing heterocycles are important chemical entities and key structural motifs in many biologically active molecules, representing valuable but synthetically challenging building blocks. Herein, we report a new method for the construction of sulfur-containing heterocycles under mild conditions using a green oxidative system composed of HBr and DMSO. This transformation employs inexpensive and readily available thiophenols as the sulfur source, operates without external photocatalysts and metals, and offers a general approach for the construction of small-ring and bridged-ring systems.
Authors
- Dayong Shi (ORCID: https://orcid.org/0000-0001-8941-5285)
- Ruihua Liu (ORCID: https://orcid.org/0000-0002-2517-1581)
- Cong Shi (ORCID: https://orcid.org/0009-0000-5681-3834)
- Yuanyuan Zhao (ORCID: https://orcid.org/0000-0003-4264-7665)
- Yingze Shu
- Shuhan Zhu
- Xiangqian Li
- Zemin Wang
- Ruyue Zhang
- Yue Xu
- Chao Liu
- Hongyun Qin
- Chao Xie (ORCID: https://orcid.org/0009-0003-8238-5580)
Institutions
- Shandong University of Technology (CN)
- Shandong University (CN)
- City University of Hong Kong, Shenzhen Research Institute (CN)
- Shandong University of Science and Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-09-14
- DOI
- https://doi.org/10.1021/acs.orglett.6c03487
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- Science, Technology and Innovation Commission of Shenzhen Municipality
- Key Technology Research and Development Program of Shandong