The role of N6-methyladenosine (m6A) modification in the development and progression of head and neck squamous cell carcinoma (HNSCC): mechanistic insights and translational challenges
{"Head":[0],"and":[1,28,31,48,65,68,89,91,110,122,133,153,163,175,191,205,234,247,264,282,296,304,310,336],"neck":[2,32],"squamous":[3],"cell":[4],"carcinoma":[5],"(HNSCC)":[6],"ranks":[7],"as":[8,107,215],"the":[9,19,23,78,83,130,184,210,252,265,276,290,300,305,328],"sixth":[10],"most":[11,131,326],"prevalent":[12],"malignancy":[13],"worldwide,":[14],"encompassing":[15],"tumors":[16],"derived":[17],"from":[18,315],"mucosal":[20],"epithelia":[21],"of":[22,62,150,194,202,213,237,251,268,278,293,327],"oral":[24],"cavity,":[25],"pharynx,":[26],"larynx":[27],"other":[29],"head":[30],"regions.":[33],"Most":[34],"patients":[35],"are":[36],"diagnosed":[37],"at":[38],"an":[39],"advanced":[40],"stage":[41],"due":[42],"to":[43,81,92,118,318,348],"limited":[44],"early":[45],"screening":[46],"tools":[47],"nonspecific":[49],"initial":[50],"symptoms,":[51],"a":[52,57,148,169,216,222,245,256,312],"situation":[53],"that":[54,180,224,325],"correlates":[55],"with":[56,255],"poor":[58],"prognosis,":[59],"high":[60],"rates":[61],"local":[63],"recurrence":[64],"distant":[66],"metastasis,":[67],"low":[69],"overall":[70],"survival":[71],"(OS).":[72],"This":[73,155,242],"grim":[74],"clinical":[75,319,344],"status":[76,232],"underscores":[77],"urgent":[79],"need":[80,306],"clarify":[82],"molecular":[84],"mechanisms":[85],"driving":[86],"HNSCC":[87,195,227,285,347],"initiation":[88],"progression":[90],"develop":[93],"novel":[94],"targeted":[95],"therapeutic":[96,297],"strategies.":[97],"In":[98],"recent":[99],"years,":[100],"advances":[101],"in":[102,127,138,168,173,176,220,271,284,331,346],"epigenetic":[103,218],"research":[104],"technologies,":[105],"such":[106],"high-throughput":[108],"sequencing":[109],"mass":[111],"spectrometry-based":[112],"detection,":[113],"have":[114],"drawn":[115],"increasing":[116],"attention":[117],"N6-methyladenosine":[119],"(m6A)":[120],"modification":[121,137,200],"its":[123],"associated":[124],"m6A-binding":[125],"proteins":[126],"HNSCC.":[128,272],"As":[129],"common":[132],"well-characterized":[134],"internal":[135],"post-transcriptional":[136],"eukaryotic":[139],"messenger":[140],"RNA":[141,158],"(mRNA),":[142],"m6A":[143,181,199,214,269,279],"is":[144],"dynamically":[145],"regulated":[146],"by":[147,197],"network":[149,156],"\\"writers,\\"":[151],"\\"erasers,\\"":[152],"\\"readers.\\"":[154],"modulates":[157],"metabolism,":[159],"including":[160],"splicing,":[161],"stability,":[162],"translation—further":[164],"regulating":[165],"gene":[166],"expression":[167],"context-dependent":[170,266],"manner.":[171],"Accumulating":[172],"vitro":[174],"vivo":[177],"evidence":[178,302,329],"demonstrates":[179],"regulators":[182,270],"modulate":[183],"proliferation,":[185],"migration,":[186],"invasion,":[187],"epithelial–mesenchymal":[188],"transition":[189],"(EMT)":[190],"immune":[192,262],"evasion":[193],"cells":[196],"altering":[198],"levels":[201],"key":[203],"oncogenes":[204],"tumor":[206],"suppressor":[207],"genes.":[208],"Despite":[209],"recognized":[211],"role":[212],"critical":[217],"regulator":[219],"HNSCC,":[221],"synthesis":[223,250],"simultaneously":[225],"incorporates":[226],"subsite":[228],"heterogeneity,":[229],"human–papillomavirus":[230],"(HPV)":[231],"stratification,":[233],"evidence-graded":[235],"evaluation":[236],"translational":[238,291],"potential":[239],"remains":[240,334],"limited.":[241],"review":[243,333],"provides":[244],"subsite-aware":[246],"translationally":[248],"focused":[249],"available":[253],"evidence,":[254],"particular":[257],"emphasis":[258],"on":[259],"HPV":[260],"status,":[261],"regulation,":[263],"functions":[267],"We":[273],"systematically":[274],"summarize":[275],"roles":[277],"writers,":[280],"erasers,":[281],"readers":[283],"subtype-specific":[286],"biology,":[287],"critically":[288],"evaluate":[289],"prospects":[292],"m6A-related":[294],"biomarkers":[295],"targets,":[298],"acknowledging":[299],"current":[301],"limitations":[303],"for":[307,343],"prospective":[308],"validation,":[309],"propose":[311],"phased":[313],"roadmap":[314],"mechanistic":[316],"insights":[317],"application.":[320],"It":[321],"should":[322],"be":[323],"emphasized":[324],"discussed":[330],"this":[332],"preclinical,":[335],"no":[337],"m6A-targeted":[338],"therapy":[339],"has":[340],"been":[341],"validated":[342],"use":[345],"date.":[349]}
Authors
- Mengfei Yu (ORCID: https://orcid.org/0000-0002-7700-4697)
- Ziyao Jin
- Zihe Hu (ORCID: https://orcid.org/0000-0003-4191-0927)
- Junjie Luo (ORCID: https://orcid.org/0000-0002-8987-0533)
- Kun Li (ORCID: https://orcid.org/0000-0002-2026-9969)
- Zhichao Liu (ORCID: https://orcid.org/0000-0002-3379-6258)
- Yuqi Lin (ORCID: https://orcid.org/0000-0002-3019-5684)
- Lianjie Peng
- Shengzhong Duan (ORCID: https://orcid.org/0000-0002-4866-3167)
- Shihan Wang
- Yuting Li
- Xin Ye
Institutions
- Sir Run Run Shaw Hospital (CN)
- Tongde Hospital of Zhejiang Province (CN)
- Zhejiang University Medical College Affiliated Stomatological Hospital (CN)
- Stomatology Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2026-09-13
- DOI
- https://doi.org/10.1186/s40001-026-05188-w
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00