Fabrication and in Vitro Evaluation of Photothermal‐Responsive Nanofibers Loaded With Tannic Acid‐Copper Complexes

ABSTRACT The excessive use of antibiotics has led to an increasingly serious problem of bacterial resistance, which poses challenges for the clinical treatment of skin wound infections and urgently requires the development of new antibacterial strategies. This study synthesized tannic acid‐copper complexes (TA@Cu) based on the metal‐polyphenol coordination principle and loaded them onto carboxymethyl chitosan (CMCS)‐based nanofibers to prepare composite nanofibers (TA@Cu CPNFs) with a uniform fiber network structure. Under 808 nm laser irradiation of 1.3 W/cm 2 , TA@Cu CPNFs rapidly heated up to 50.0°C with excellent cycling stability. In addition, the antibacterial activity of the nanofibers against S. aureus and E. coli was > 95%, indicating a broad spectrum of antibacterial potential. Moreover, these nanofibers demonstrated excellent antioxidant activity and good biocompatibility. In summary, these nanofibers with photothermal‐chemical synergistic antibacterial activity show great clinical application potential in the treatment of bacterial skin infections.