The chain and its test points: a testable model linking sensory throughput, thiol reserve and copper delivery in post-COVID illness, fatigue and sensory hypersensitivity

Version 1.1 (13 September 2026): The vitamin K cycle is added as an eighth test point (gap G8) with two new falsifiable predictions (P9, P10) and fourteen additional references. With it the model closes into a circle: peroxynitrite, the endpoint of the chain as described in version 1.0, acts through S-nitrosylation of thioredoxin-like domains on vitamin K reduction, and through undercarboxylated matrix Gla protein back onto calcium distribution, where the chain begins. A figure of the closed chain has been added to section 1. Version 1.0 remains citable under the same concept DOI.

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-09-13
DOI
https://doi.org/10.5281/zenodo.22735808
Primary Topic
Vitamin K Research Studies
Type
preprint
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preprint

The chain and its test points: a testable model linking sensory throughput, thiol reserve and copper delivery in post-COVID illness, fatigue and sensory hypersensitivity

Nancy Vauthey
Zenodo (CERN European Organization for Nuclear Research)
Vitamin K Research Studies
preprint

The chain and its test points: a testable model linking sensory throughput, thiol reserve and copper delivery in post-COVID illness, fatigue and sensory hypersensitivity

Nancy Vauthey
preprint en

Abstract

Version 1.1 (13 September 2026): The vitamin K cycle is added as an eighth test point (gap G8) with two new falsifiable predictions (P9, P10) and fourteen additional references. With it the model closes into a circle: peroxynitrite, the endpoint of the chain as described in version 1.0, acts through S-nitrosylation of thioredoxin-like domains on vitamin K reduction, and through undercarboxylated matrix Gla protein back onto calcium distribution, where the chain begins. A figure of the closed chain has been added to section 1. Version 1.0 remains citable under the same concept DOI.

Zenodo (CERN European Organization for Nuclear Research)
Good health and well-being
Vitamin K Research Studies
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