5-Amino pyrimidine synthesis via azirine skeletal remodelling.
a cascade of condensation, intramolecular cyclisation, strain-release-driven azirine ring-opening, and aromatisation. This step-economical strategy highlights the untapped potential of strained azirines as versatile synthons for the synthesis of biologically potent 2,4-arylpyrimidin-5-amines.
Authors
- Virender Singh (ORCID: https://orcid.org/0000-0003-4242-5421)
- A. Chaturvedi (ORCID: https://orcid.org/0009-0008-2407-1328)
- Vishal Sharma (ORCID: https://orcid.org/0000-0002-5130-1626)
Institutions
- Central University of Punjab (IN)
- Maharaja Ranjit Singh Punjab Technical University (IN)
Publication Details
- Journal
- PubMed
- Published
- 2026-09-11
- DOI
- https://doi.org/10.1039/d6cc04958c
- Primary Topic
- Synthesis and Catalytic Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00