THYROID DYSFUNCTION IN PATIENTS OF CHRONIC KIDNEY DISEASE -AN OBSERVATION STUDY

Background: Thyroid hormones are essential for regulating metabolism, development, protein synthesis, and other hormonefunctions. CKD has been linked to changes in the pituitary-thyroid axis and peripheral thyroid hormone metabolism.Materials and Methods: A cross-sectional study was conducted in 100 subjects from September 2019 to September 2021 inthe Department of Medicine, Goa Medical College, Goa. A tertiary care hospital in Goa. Results: Most of the CKD patientsin study population are in the Age group of 41 – 70 years. 70% are male. 54% patients were diabetic and 46% patients werenon diabetic, majority of them 87% patients were hypertensive, majority of them were DM and HTN With 88% and fewpatients belongs to other diseases. 8% patients with high TSH level, 6% with low TSH level, 86 % with normal TSH level.TT4 levels were low in 28% patients and normal in 72% patients, TT3 levels were high in 3% patients, low in 60% andnormal in 37% patients. FT4 levels were high in 5% patients and low in 7%, normal in 88% patients. FT3 levels were high in1% patients, low in 49%, normal in 50% patients. 55% patients belongs to euthyroid state and 7% patients belongs tohypothyroid state and 36% patients belongs to Sick euthyroid state and 2% belongs to Subclinical thyrotoxicosis.Conclusion: Most of the participants in this study were euthyroid. The most common thyroid hormone derangement waslow T3 values (non-thyroidal illness). The prevalence of hyperthyroidism in this study (2%) and hypothyroidism 7%.