Metastatic immune microenvironment remodeling by malignant epithelial cells drives colorectal cancer hepatic metastasis: Multi-omics insights

{"Background":[0],"Advanced":[1],"CRC":[2,33,48,118,233,257],"patients":[3,258],"frequently":[4],"accompanied":[5],"by":[6,142,235],"hepatic":[7,199],"metastasis":[8],"(HM).":[9],"Malignant":[10],"epithelial":[11,30,56,60,91,115,131,157,224],"cells,":[12],"as":[13],"the":[14,26,196,208,227],"core":[15],"in":[16,32,117,128,219,256],"metastasis,":[17],"have":[18],"not":[19],"been":[20,121],"fully":[21],"investigated.":[22],"This":[23],"study":[24],"investigates":[25],"role":[27],"of":[28,47,113,198,211],"malignant":[29,55,114],"cells":[31,92,116,158,225],"HM":[34,119,205,234],"and":[35,80,93,101,138,166,175,183,203,215,240],"its":[36],"underlying":[37],"mechanisms.":[38],"Methods":[39],"Multi-omics":[40],"were":[41,82,105,126,140],"utilized":[42,65,83,106],"to":[43,53,66,84,144,186,231,251],"perform":[44],"comprehensive":[45],"analysis":[46],"HM.":[49,220,260],"\\"Scissor\\"":[50],"was":[51,64],"employed":[52],"identify":[54,85],"cell":[57],"(Scissor":[58],"+":[59,90,130,156,161,168,188,213,217,223,238,242],"cell).":[61],"Furthermore,":[62,244],"\\"MIME\\"":[63,143],"establish":[67],"a":[68],"HM-associated":[69],"prognostic":[70],"signature":[71],"for":[72,107],"calculating":[73],"Scissor-related":[74],"risk":[75],"score":[76,247],"(SRRS).":[77],"Then,":[78,133],"\\"CellChat\\"":[79],"\\"NicheNet\\"":[81],"significant":[86],"crosstalk":[87],"between":[88],"Scissor":[89,129,155,222],"various":[94],"immunosuppressive":[95],"cells.":[96,132],"Finally,":[97],"RT-qPCR,":[98],"Western":[99],"blotting":[100],"Transwell":[102],"migration":[103],"assays":[104],"validation.":[108],"Results":[109],"The":[110],"heterogeneity":[111],"landscape":[112],"has":[120],"delineated.":[122],"Notably,":[123],"EMT-related":[124],"pathways":[125],"enriched":[127],"three":[134],"genes":[135],"(HSPB1,":[136],"HEBP2":[137],"ZFP36L1)":[139],"identified":[141],"calculate":[145],"SRRS.":[146],"Higher":[147],"SRRS":[148,246],"scores":[149],"indicate":[150],"worse":[151],"patient":[152],"prognosis.":[153],"Intriguingly,":[154],"recruit":[159],"CD4":[160,212,237],"Treg":[162,214,239],"(Regulatory":[163],"T":[164,171],"cells)":[165,172],"CD8":[167],"Tex":[169],"(Exhausted":[170],"via":[173],"MIF":[174],"MK":[176],"pathways,":[177],"while":[178],"simultaneously":[179],"attracting":[180],"normal":[181],"macrophages":[182,190],"convert":[184],"them":[185],"SELENOP":[187,216,241],"tumor-associated":[189],"(TAMs)":[191],"through":[192],"LGALS9-HAVCR2":[193],"axis.":[194],"Moreover,":[195],"comparison":[197],"immune":[200,229],"microenvironment":[201,230],"before":[202],"after":[204],"further":[206],"substantiates":[207],"critical":[209],"roles":[210],"TAMs":[218],"Conclusions":[221],"reshape":[226],"metastatic":[228],"promote":[232],"recruiting":[236],"TAMs.":[243],"higher":[245],"can":[248],"be":[249],"used":[250],"predict":[252],"unfavorable":[253],"clinical":[254],"outcomes":[255],"with":[259]}