Inhibition of the Wnt/β-Catenin pathway via an LGK974–cyclodextrin inclusion complex alleviates cardiac injury
cells, suggesting an immunomodulatory effect. These findings indicate that CD:LGK974 attenuates cardiac injury and modulates immune response in T. cruzi-infected mice. Together, these results highlight its potential as a therapeutic strategy for reducing pathological cardiac remodeling associated with T. cruzi infection.
Authors
- Sérgio Scalzo (ORCID: https://orcid.org/0000-0002-1496-878X)
- Pedro Pires Goulart Guimarães (ORCID: https://orcid.org/0000-0003-4534-2779)
- Ricardo Toshio Fujiwara (ORCID: https://orcid.org/0000-0002-4713-575X)
- Pedro Augusto Carvalho Costa (ORCID: https://orcid.org/0000-0002-3240-7513)
- Pedro Henrique Dias Moura Prazeres (ORCID: https://orcid.org/0000-0002-1933-3230)
- Walison N. Silva (ORCID: https://orcid.org/0000-0003-2654-7795)
- Luísa Mourão Dias Magalhães (ORCID: https://orcid.org/0000-0001-9957-3295)
- Natália Jordana Alves da Silva (ORCID: https://orcid.org/0000-0002-0032-7084)
- Ana Luiza de Castro Santos
- Marcelo Eduardo Cardozo (ORCID: https://orcid.org/0009-0000-4337-625X)
- Silvia Guatimosim
- Lilian Lacerda Bueno (ORCID: https://orcid.org/0000-0003-3510-4590)
- Victor Moura Vidal
- Ivan Lobo
- Guilherme Costa
- Artur Miranda
Institutions
- Universidade Federal de Minas Gerais (BR)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2026-09-12
- DOI
- https://doi.org/10.1016/j.biopha.2026.119859
- Primary Topic
- Wnt/β-catenin signaling in development and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais
- Pró-Reitoria de Pesquisa, Universidade Federal de Minas Gerais