PPARGC1A Gly482Ser POLYMORPHISM AS A MOLECULAR GENETIC PREDICTOR OF EMBRYONIC LOSS IN WOMEN WITH RECURRENT MISCARRIAGE

Recurrent miscarriage remains one of the most challenging problems in modern obstetrics and reproductive medicine. Despite advances in diagnostic technologies, the causes of early embryonic loss remain unclear in a substantial proportion of cases. Current evidence suggests that genetically determined disturbances of energy metabolism, hemostasis, folate metabolism, and placental microcirculation may contribute to impaired implantation and early embryonic development. Particular attention has recently been paid to the PPARGC1A gene, which is involved in mitochondrial biogenesis, oxidative metabolism, cellular energy homeostasis, and adaptive responses to metabolic stress. Functional polymorphisms of this gene may influence the metabolic stability of trophoblastic and decidual tissues during early gestation and thereby contribute to pregnancy failure.