Inflammatory Cytokines as Biologic Signatures of the Effect of Dietary Supplementation With Omega Fatty Acids on Autism-Related Behaviors and Features Among Young Children: A Randomized Controlled Trial
{"PURPOSE:":[0],"Evidence":[1],"for":[2,15,87,182,216,222],"the":[3,48,115,122,223],"efficacy":[4],"of":[5,47,50,117,225],"dietary":[6,52],"omega":[7,83,118,226],"fatty":[8,228],"acid":[9],"supplementation":[10,22,53,120],"as":[11,44,219],"a":[12,220,245],"supportive":[13],"intervention":[14],"autism":[16,184],"is":[17],"mixed.":[18],"Mechanisms":[19],"by":[20,102,146],"which":[21],"may":[23,29],"offer":[24],"benefit":[25],"are":[26],"unclear.":[27],"Inflammation":[28],"contribute":[30],"to":[31,82],"autism-related":[32,96,138,173,201,231],"behaviors":[33,97,139,174,202,232],"and":[34,56,59,95,98,105,113,135,140,151,175,203,233],"features.":[35,141,204],"This":[36,211],"double-blind,":[37],"randomized":[38,81],"controlled":[39],"trial":[40],"evaluated":[41,114],"inflammatory":[42],"cytokines":[43,134,171,194],"biologic":[45],"signatures":[46],"effect":[49,116,169,224],"daily":[51],"with":[54,76,198],"omega-3":[55],"omega-6-rich":[57],"fish":[58],"borage":[60],"oil":[61],"(\\"omega":[62],"3-6\\")":[63],"versus":[64],"placebo":[65,86],"in":[66,93,124,133,137,161,180,193,200,244],"children":[67,156],"ages":[68],"2":[69],"-":[70],"<":[71],"7":[72],"years":[73],"recently":[74],"diagnosed":[75],"autism.":[77],"METHODS:":[78],"Children":[79],"were":[80,91,100,159,195,208],"3-6":[84,119,165,227],"or":[85,172],"90":[88],"days.":[89],"Cytokines":[90],"measured":[92],"plasma,":[94],"features":[99,176,234],"assessed":[101],"caregiver":[103],"report":[104],"direct":[106],"assessment.":[107],"Linear":[108],"mixed":[109],"models":[110],"followed":[111],"intent-to-treat":[112],"on":[121,170,230],"change":[123,132,136,181],"cytokines.":[125],"Pearson":[126],"correlation":[127],"coefficients":[128],"estimated":[129],"associations":[130],"between":[131],"Exploratory":[142],"analyses":[143],"examined":[144],"moderation":[145],"sex,":[147],"age,":[148],"gastrointestinal":[149],"symptoms,":[150],"overweight.":[152],"RESULTS:":[153],"Of":[154],"98":[155],"randomized,":[157],"96":[158],"included":[160],"this":[162],"analysis.":[163],"Omega":[164],"had":[166],"no":[167],"overall":[168],"(e.g.,":[177],"group":[178],"difference":[179],"PDDBI":[183],"composite":[185],"=":[186],"0.1,":[187],"95%":[188],"CI=":[189],"-10.9,":[190],"11.1).":[191],"Changes":[192],"generally":[196],"uncorrelated":[197],"changes":[199],"Some":[205],"sex-specific":[206,239],"effects":[207,240],"observed.":[209],"CONCLUSION:":[210],"study":[212],"offered":[213],"little":[214],"support":[215],"inflammation":[217],"serving":[218],"mechanism":[221],"acids":[229],"among":[235],"young":[236],"children.":[237],"Suggestive":[238],"should":[241],"be":[242],"replicated":[243],"larger":[246],"trial.":[247],"CLINICAL":[248],"TRIAL":[249],"REGISTRY:":[250],"Clinicaltrials.gov":[251],"NCT04312932":[252],"registered":[253],"March":[254],"16,":[255],"2020.":[256]}
Authors
- Sarah A. Keim (ORCID: https://orcid.org/0000-0003-3490-3649)
- Lisa M. Robinette (ORCID: https://orcid.org/0000-0002-9314-9538)
- P. L. Taylor
- Lin Sun (ORCID: https://orcid.org/0000-0002-4173-6204)
- Lynette K. Rogers
- Daniel L. Coury
- Joseph Rausch
- Kelly A. McNally
Institutions
- Nationwide Children's Hospital (US)
- The Ohio State University (US)
Publication Details
- Journal
- Journal of Autism and Developmental Disorders
- Published
- 2026-09-12
- DOI
- https://doi.org/10.1007/s10803-026-07523-w
- Primary Topic
- Fatty Acid Research and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Center for Advancing Translational Sciences
- National Center for Complementary and Integrative Health