New Approaches to the Synthesis of 6-Amino-4-aryl-5-(4-arylthiazol-2-yl)-2-methoxynicotinonitriles
Abstract Reactions of (2E)-3-aryl-2-(4-arylthiazol-2-yl)acrylonitriles, malononitrile, and sodium methoxide or 2-[4-(4-bromophenyl)thiazol-2-yl]acetonitrile, 4-methoxybenzylidenemalononitrile, and potassium hydroxide in methanol proceed to give 6-amino-4-aryl-5-(4-arylthiazol-2-yl)-2-methoxynicotinonitriles in 38–47% yields.
Authors
- D. V. Nikitenko (ORCID: https://orcid.org/0000-0001-6902-8114)
- Andrei V. Churakov (ORCID: https://orcid.org/0000-0003-3336-4022)
- N. A. Pakholka (ORCID: https://orcid.org/0000-0003-0292-6002)
- С. Г. Кривоколыско (ORCID: https://orcid.org/0000-0001-9879-9217)
Institutions
- NS Kurnakova Institute of General and Inorganic Chemistry (RU)
- Institute of Physical and Organic Chemistry (BY)
- Luhansk State Medical University (UA)
Publication Details
- Journal
- Russian Journal of General Chemistry
- Published
- 2026-09-12
- DOI
- https://doi.org/10.1134/s1070363226601766
- Primary Topic
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00