Appendix B: Natural Philosophy-Based Eternal Life Theory: A Novel Regulatory Mechanism of Human Aging

This pre-print manuscript entitled Natural-philosophy-based Theory of Life-Immortality proposes an original and previously unreported mechanism of human aging derived from top-down natural philosophical deduction built upon personal physiological observations from five all-night wakefulness episodes. Human aging progression is synergistically regulated by endogenous melatonin, adenosine, and intracellular ATP metabolism. Photoperiod and sleep rhythm reshape the secretion rhythm and concentration of melatonin in vivo, further governing the accumulation rate of internal adenosine. This deduction identifies adenosine both as the sleep-inducing substance and a key driver of biological aging. Excessive adenosine triggers mitochondrial oxidative stress damage, accelerates telomere wear, and induces continuous progressive biological aging in the human body. This work originates from phenomenological reasoning rather than laboratory experiments. Academic researchers in endocrinology, geroscience, sleep medicine, and pharmacology are welcome to conduct academic exchanges and theoretical discussion. If the theoretical framework gains experimental validation in future work, it will establish an entirely new research direction for anti-aging intervention and human lifespan extension research.