Molecular profile of aging in men: Transcriptome panel to evaluate 21 mechanisms of aging

{"This":[0],"work":[1],"is":[2,119,135],"a":[3,12,100],"comprehensive":[4],"roadmap":[5],"for":[6,15,150],"the":[7,17,61,72,77,89,107,112,130,143],"development":[8],"and":[9,38,41,54,82,92,115,132,153],"validation":[10],"of":[11,20,36,60,79,95,129,146,156],"PCR":[13],"panel":[14,31,63],"assessing":[16],"molecular":[18],"profile":[19],"aging":[21,37,73,157],"in":[22,45,71,102],"men,":[23],"which":[24,140],"has":[25],"yet":[26],"to":[27,51,121,136],"be":[28,43,137],"implemented.":[29],"The":[30,57],"will":[32,42],"cover":[33],"21":[34],"mechanisms":[35,109],"48":[39],"genes":[40,124],"deployed":[44],"six":[46],"stages,":[47],"from":[48],"design":[49],"formation":[50],"regulatory":[52],"approval":[53],"clinical":[55],"implementation.":[56],"key":[58],"features":[59],"male":[62,116],"are":[64],"determined":[65],"by":[66,111],"two":[67],"main":[68],"\\"turning":[69],"points\\"":[70],"trajectory":[74],"—":[75,85],"at":[76],"age":[78],"about":[80],"35":[81],"50":[83],"years":[84],"as":[86,88],"well":[87],"earlier":[90],"onset":[91],"higher":[93],"rate":[94],"transcriptomic":[96,131],"shifts":[97],"associated":[98],"with":[99],"decrease":[101],"sex":[103],"hormone":[104],"levels.":[105],"For":[106],"nine":[108],"characterized":[110],"greatest":[113],"heterogeneity":[114],"specificity,":[117],"it":[118],"planned":[120],"use":[122],"three":[123],"each.":[125],"A":[126],"comparative":[127],"analysis":[128,149],"epigenetic":[133],"approaches":[134],"carried":[138],"out,":[139],"should":[141],"show":[142],"fundamental":[144],"advantages":[145],"gene":[147],"expression":[148],"subsequent":[151],"comparison":[152],"personalized":[154],"management":[155],"processes.":[158]}

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-09-11
DOI
https://doi.org/10.5281/zenodo.22711876
Primary Topic
Molecular Biology Techniques and Applications
Type
preprint
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
preprint

Molecular profile of aging in men: Transcriptome panel to evaluate 21 mechanisms of aging

Лагода
Zenodo (CERN European Organization for Nuclear Research)
Molecular Biology Techniques and Applications
preprint

Molecular profile of aging in men: Transcriptome panel to evaluate 21 mechanisms of aging

Лагода
preprint en

Abstract

This work is a comprehensive roadmap for the development and validation of a PCR panel for assessing the molecular profile of aging in men, which has yet to be implemented. The panel will cover 21 mechanisms of aging and 48 genes and will be deployed in six stages, from design formation to regulatory approval and clinical implementation. The key features of the male panel are determined by two main "turning points" in the aging trajectory — at the age of about 35 and 50 years — as well as the earlier onset and higher rate of transcriptomic shifts associated with a decrease in sex hormone levels. For the nine mechanisms characterized by the greatest heterogeneity and male specificity, it is planned to use three genes each. A comparative analysis of the transcriptomic and epigenetic approaches is to be carried out, which should show the fundamental advantages of gene expression analysis for subsequent comparison and personalized management of aging processes.

Zenodo (CERN European Organization for Nuclear Research)
Good health and well-being
Molecular Biology Techniques and Applications
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Molecular profile of aging in men: Transcriptome panel to evaluate 21 mechanisms of aging — Лагода · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS